ABSTRACT
Objective To explore thyroid related hormones levels and clinical significance of the different gestational age pregnant women.Methods 80 pregnant women for prenatal examination in our hospital were selected,including early pregnancy group 26 cases,mid -term group 33 cases and late pregnancy group 21 cases. They were taken venous blood centrifugal separation of serum,automatic biochemical analyzer was used to detect thyroid stimulating hormone (TSH),free triiodothyronine three (FT3 ),free thyroxine (FT4 )levels and associated hormone levels during pregnancy were compared.Results TSH level of early pregnancy group (1.28 ±0.23)mIU /L and mid -term group (1.56 ±0.28)mIU /L were significantly lower than non -pregnant (1.95 ±0.35)mIU /L(t =8.12,7.61,all P 0.05).A -TG positive rate (4.76%)and TPOAb positive rate (4.76%)of late pregnancy group was significantly lower than the early pregnancy group and mid -term group (χ2 =9.10,9.65,8.89,7.56,all P <0.05).Conclusion The levels of thyroid related hormone in different gestational age and autoantibody positive rate had significant differences, clinical pregnancy checks should be strengthened and control in the normal range,in order to achieve the purpose of prenatal and postnatal care.
ABSTRACT
Objective To evaluate the effectiveness of the Michigan neuropathy screening instrument (MNSI),the Michigan Diabetic Neuropathy Score(MDNS) and the Toronto Clinical Scoring System(TCSS) in screening diabetic peripheral neuropathy (DPN) in order to find a rapid,simple and accurate way for DPN screening.Methods Three hundred and twenty-seven type 2 diabetic patients were enrolled in the study.All patients received the 4 simple tests including MNSI,MDNS,TCSS and neural electrophysiological test (NET).Taking the results of NET as the golden criteria,the sensitivity,specificity,positive and negative predictive values,accuracy,Youden indexes and Kappa values of the scoring systems were analyzed to evaluate their clinical effectiveness.Results Compared with NET examination,sensitivity,specificity and accuracy of MDNS were 90.5％ (162/179),68.92％ (102/148),80.73％ (264/327),and 87.71％ (157/179),78.38％ (116/148),83.49％ (273/327) for MNSI and 79.33％ (142/179),65.54％ (97/148),73.09％ (239/327) for TCSS.MNSI and MDNS were better than TCSS in terms of effectiveness of DPN diagnosis and consistence with the result of NET (MDNS:0.6 045 ; MNSI:0.6 648 ; TCSS:0.4524).The area under the ROC curve of MNSI,MDNS and TCSS were 0.757,0.719,0.667.Conclusion Among the three scales methods,MNSI is a better method in screening DPN for its simplicity and reliability.