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Introduction: Thyroid cancer is on the developing world over– almost doubling in the past ten years. This is mainly due toimproved awareness, screening and diagnosis of the nodulardisease. Thyroid cancer has an apparent gender predispositionwith women being affected three times more than men and8th most mostly occurring cancer among women. To analyzethe clinicopathological profile of thyroid cancer patients andto assess the pattern of treatment and long-term treatmentoutcomes.Material and methods: The current study was retrospectivecase record review of all the thyroid cancer cases includingall the histopathological confirmed cases of thyroid cancer.The statistical analysis was carried out by using IBM SPSSversion 21.Results: A total of 67 subjects were included with a meanage of 44.72 ± 14.99 years. Females were 68.66% andmales 31.34% of the study population, 61 (91.05%) peoplehad usual presentation of neck swelling of various sizes andother associated findings. Thyroid function test showed that91.04% (61) showed euthyroid status, 40.3% (27) had a totalthyroidectomy, 95.52% (64) of the patients were alive andwell.Conclusion: The study bears evidence to the fact thatpapillary carcinoma is the most commonly occurring formof differentiated thyroid cancer (70.6%). The prevalence ofdistant metastasis is 4.48% and most commonly found in thelung. The disease is more prevalent among women than men
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Aim: The present study was aimed to synthesis and characterization of silver nanoparticles (AgNPs) using Zanthoxylum ovalifolium leaf essential oil extracts and to screen the anti-oxidant and antimicrobial potential of the same. Place and Duration of Study: The studies were carried out at Department of Botany, AVK College for Women, Hassan and Department of Biochemistry, Aurora’s Degree & PG College, Hyderabad from July 2017 to June 2018 Methodology: The essential oil from leaves of Zanthoxylum ovalifolium was obtained by hydrodistillation and analyzed by GC and GC-MS. Synthesis of silver nanoparticles of essential oil extract was carried out and characterized by using UV-VIS spectroscopy and transmission electron microscopy (TEM). The total phenolic and flavonoid contents were estimated in all the extracts. Furthermore, all the extracts were evaluated for anti-microbial activity against two gram-positive and two gram-negative bacteria and four pathogenic fungi using agar disc diffusion technique. Subsequently the minimum inhibitory concentration (MIC) was also determined. Results: The major compounds identified were Limonene, isofenchol, Geijerene, isothujanol, Borneol, dihydrocarveol, isobornyl acetate, pregeijerene, b-elemene, trans-caryophyllene and Germacrene D. The TEM analysis of nanoparticles synthesized showed a size of 8 to 14 nm with a lmax of 450nm. All the extracts were evaluated for in vitro anti-oxidant activity where the AgNP of essential oil extract showed maximum activity of 89.61% and 84.92% respectively for both DPPH free radical scavenging and Hydrogen peroxide free radical scavenging assays at a concentration of 100µg/ml. Among all the bacteria tested, B. subtilis was most susceptible at 100µg/ml with zone of inhibition of 22.5mm. While among all the fungi tested, A. niger inhibited more effectively by the AgNP of essential oil extract at 100µg/ml with a zone of inhibition of 16.2mm. Conclusion: The results obtained were remarkable suggesting that AgNP of essential oil extract possess excellent anti-oxidant and anti-microbial activity and can be an alternative bio-friendly source for various pharmaceutical industries.
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Introduction: Maternally Inherited Diabetes and Deafness(MIDD), a specific clinical syndrome results in sensory neuralhearing defect in diabetes population which may lead toA3243G mutation in tRNALeu (UUR) gene.Materials and methods: A prospective case control study, thenon probability convenient sampling technique was followedin this study. The subjects were divided into non diabetic anddiabetic with maternal inheritance groups. Hundred patientswith the strong maternal history of diabetes is group 1 andhundred non diabetic individuals with no maternal history ofdiabetes is group 2. Blood and urine samples were collectedand analyzed biochemical parameters among the two groups.In addition, audiometric analysis was also carried out for thosegroups.Results: The mean age of onset of diabetes was 41 yearsand deafness was 51 years. The mean plasma glucose,Glycosylated Hemoglobin(HbA1C), Serum Insulin, InsulinResistance, Cholesterol, Triacyl glycerides, Very Low DensityLipoprotein(VLDL), Low Density Lipoprotein, SerumUrea, Serum Uric acid, Serum Creatinine and Albumin toCreatinine Ratio (ACR) levels in patients were significantlyhigher whereas High Density Lipoproteins(HDL) and urinecreatinine levels were significantly low as compared withcontrols. The mean Body Mass Index (BMI) is slightly higherin patients as compared with control group.Conclusion: The study helps us to understand that theMaternally Inherited Diabetes and Deafness syndromeseverely alters the insulin resistance level, ACR ratio and lipidprofile which may lead to multiple organ disorder at early ageof diabetes.
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No abstract available.
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Ghee (clarified butter) has generally been assumed to be hypercholesterolaemic on the basis of its composition but there is hardly any study to support or refute the assumption. The present study was conducted on sixty-three healthy, young, physically active adult volunteers (52 male, 11 female). The study design was that of a randomized controlled trial with a parallel design. After a lead-in period of 2 wk, the subjects were randomly divided into two groups, Group A (n = 30; 25 male, 5 female) and Group B (n = 33; 27 male, 6 female). Group A (experimental) consumed for 8 wk a diet in which ghee provided 10% of the energy intake. The only other visible fat in the diet was mustard oil, and total energy from fats was 25% of the energy intake. Group B (control) consumed for 8 wk a similar diet except that all visible fat came from mustard oil. The serum total cholesterol level showed a significant rise in the experimental group at 4 wk; the rise persisted at 8 wk. A similar rise was also seen in HDL cholesterol. Hence the total cholesterol/HDL cholesterol ratio did not show any significant change. In the control group, there was a trend towards a fall in LDL cholesterol but the change was not significant. The study does not indicate any adverse effect of ghee on lipoprotein profile. However, more studies are needed on older subjects, hyperlipidaemic subjects, and on subjects following less healthy lifestyles before the results of this study can be extrapolated to the general population.
Subject(s)
Adult , Cholesterol/blood , Dietary Fats/administration & dosage , Female , Humans , Male , Mustard Plant , Plant Extracts/administration & dosage , Plant Oils , Triglycerides/bloodABSTRACT
Tinctures of Eclipta alba were prepared by using 30, 40, 50, 60, 70, 80, 90 and 100% of alcohol by maceration process for 10, 20 and 30 days. Tincture by using 30% of alcohol on 30 days of maceration produced maximum yield of total solid content and showed pH -7.58. It was characterized by studying various co-chemical characteristics
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A randomised controlled trial with a parallel design was conducted on 24 healthy young volunteers who were divided into two groups. After a lead-in period of 2 wk, the experimental group (n = 11; 9 male, 2 female) had for 8 wk a lactovegetarian diet providing about 25% of the energy intake in the form of fat, of which ghee provided 10 en% and the remaining fat energy came from mustard oil and invisible fat. The control group (n = 13; 8 male, 5 female) had a similar diet except that all visible fat was in the form of mustard oil. In neither group was there any significant change in the serum lipid profile at any point in time. At 8 wk, 2 volunteers in the experimental group, and 1 volunteer in the control group had more than 20% rise in serum total cholesterol as compared to their 0 wk values. There was also an appreciable increase in HDL cholesterol at 8 wk in the experimental group, but it was not statistically significant. Consuming ghee at the level of 10 en% in a vegetarian diet generally has no effect on the serum lipid profile of young, healthy, physically active individuals, but a few individuals may respond differently.