Polyfused heterocyclic systems derived from 4-amino- 3-aryloxymethyl -5-mercapto-s-triazoles

2-aryloxymethyl-s-triazolo [5,1-benzo-[1,3] thiazine-9[H]-ones IIa-c and 1-aryloxymethyl-s-triazolo [4,3-d] [1,2,3,4] thiatriazoles IIIa-c were prepared from 4-amino-3-aryloxymethyl-5-mercapto- 1,2,4-triazoles la-c. Other new tricyclic systems; namely, 1-aryloxymethyl-s- triazolo [3,4-b] pyrrolo [1,2-d] [1,3,4] thiadiazepine derivatives IXa-c and XIa-b were synthesized by intramolecular electrophilic substitution of some 4-pyrrolyl-s- triazole derivatives. The structure of the products was established by IR and PMR spectral data

Synthesis and central nervous system activity of some novel 4 [3H] -quinazolines including thiazolo [3,2-b] -S-triazoles

Several new 2-[2,3-disubstituted thiazolo [3, 2-b]-s-triazol-5-yl] methylthio-3-aryl-4 9[3H] quinazolinones 3a-i, 4a-c and 5a-c were synthesized. Some of the products showed some CNS depressant activities

Synthesis and antihypertensive evaluation of some phthalazines containing 1,3,4-thiadiazines and 1,3,4-thiadiazin-5-ones

Starting from methyl N2[4-methylphthalazin-1-yl]dithiocarbazinate, a number of new phthalazine derivatives containing 1, 3, 4-thiadiazine and 1, 3, 4-thiadiazin-5-one rings were prepared. The structure of the new products was confirmed by spectral analysis besides synthesis via other routes. A preliminary antihypertensive evaluation revealed that most compounds possess moderate antihypertensive activity

Synthesis and central nervous system activity of serum new sulphonyl containing quinazoline derivatives

3-phenyl-2- [3-phenyl-5-arylphrazolin-4-yl] sulphonyl-4- [3H] quinazolinones 5a-d, 3-phenyl-2- [1,3-diphenyl-5- arylpyrazolin-4-yl] sulphonyl-4 [3H]-quinazolinones 6a-d and 3- phenyl-2- [3-phenyl-5-arylisoxazolin-4-yl] sulphonyl-4 [3H]-quinazolinones 7a-d have been synthesized by the condensation of chalkones 4a-d with hydrazine hydrate, phenylhydrazine and hydroxylamine hydrochloride, respectively. The chemical structure of these compounds were confirmed by elemental analysis, IR and 1H-NMR spectral data. Some of these compounds have been tested for analgesic, anti-inflammatory and anticonvulsant activity and showed no activity

Synthesis of some quinazolines derived from 2- Hydrazino-3-aryl-4 [3H] -quinazolines

In this work certain 2-hydrazino-3-aryl-4[3H]-quinazolinones [la-c] were reacted with phenacyl bromides to give 1,2,4-triazino[4,3-a]quinazolines [2a-f]. Condensation of compound 1 with substituted omega cyanoacetophenones gave 2-[3-aryl-5-aminopyrazol-1-yl]-3-aryl-4-[3H]-quinazolinones[3a-f]. Subsequent treatment of 3 with acetyl chloride yields the corresponding acetyl-amino derivatives [4a-f], while condensation of 3 with benzoylacetone in glacial acetic acid yields pyrazolo [3,4-b]pyridine derivatives [5a-f]. The structure of these compounds were confirmed by elemental analysis, ir and 1Hnmr spectral data

Synthesis and antibacterial activity of some 1,3,4- oxadiazolines

Some N-[5-phenyltetrazol-2-ylacetyl]hydrazones [4a-f] and 4-acetyl-5-aryl-2[5-phenyltetrazol-2-ylmethyl]-1,3,4-oxadiazolines [5a-f] have been synthesized. Antibacterial activity of compounds [5a-f] were evaluated