Synthesis and biological activity of certain antipyrine derivatives

4-hydroxyantipyrine 2 reacted with different 2-chloroacetonilides to give the corresponding antipyrinyl ethers 3. Also, 4-chloro acetylaminoantipyrin 4 treated with the potassium salt of some nonsteroidal antiinflammatory acids, the potassium salt of certain ureido acids and some hydroxylated compounds afforded compounds 5, 7 and 9, respectively. The structure of the products was confirmed by microanalysis and spectral data. Preliminary pharmacological testing showed that some of these new products have demonstrated analgetic antiinflammatory effects