[Effect of lithium on neuropathic pain induced by partial ligation of rat sciatic nerve]

Background: Neuropathic pain is a type of chronic pain resulting from injury to the peripheral or central nervous system. Moreover, lithium is the main medication used to treat bipolar [manic-depression] disorder and some recent studies have also confirmed the neuroprotective effects of lithium. Considering the most common cause of neuropathic pain, nerve injury, the present study was designed to evaluate the effect of lithium on neuropathic pain induced by partial ligation of sciatic nerve in rat

Materials and Methods: This experimental study was conducted on 40 adult male rats. Neuropathic pain was induced by a partial sciatic nerve ligation model and animals were randomly divided into five groups: a control group that underwent the surgical procedure without sciatic nerve ligation and four experimental groups which received normal saline and different doses of lithium [5, 10 and 15 mg/kg, i.p.]. Heat hyperalgesia, mechanical and cold allodynia were assessed at 3, 5, 7, 10 and 14 days after surgery

Results: According to the results, lithium [5, 10 and 15 mg/kg] significantly reduced heat hyperalgesia and cold allodynia induced by partial sciatic nerve ligation [P<0.01], while it reduced mechanical allodynia only at high doses [10 and 15 mg/kg]

Conclusion: Lithium has an analgesic effect on neuropathic pain induced by partial ligation of sciatic nerve in rat. Further investigations would be needed to confirm the analgesic effect of lithium and its mechanisms of action in neuropathic pain

[Prevalence of postpartum depression and its relation to some psychosocial factors in mothers referred to health centers of Kashan during 2007-8]

Postpartum depression is a serious problem that may have negative effects on mother and family mental health. Considering that several theories have been proposed to explain the epidemiologic and demographic factors associated with the postpartum depression, the aim of this study was to identify the factors related to postpartum depression in Kashan. In this cross-sectional study, 50% of all health centers in Kashan were randomly selected during 2007-8. All of 204 mothers referred during 2-3 months of postpartum with minimum literacy [primary education] showed willingness to complete the questionnaire which included two parts: demographic and psychosocial questions and BDI [Beck Depression Inventory]. Data were analyzed using Chi-square test, CI, OR, and logistic regression. Seventy-seven [37.7%] out of 204 mothers referred to Kashan health centers experienced postpartum depression [0.31-0.44]. There was a statistically significant relationship between seven demographic and psychosocial factors and postpartum depression, in logistic regression [P<0.001], three factors [husband's appropriate behavior, intimate relationship with family, and no prior history of depression] were remained in the model. The findings indicated that the mentioned factors can reduce the incidence of postpartum depression. According to the results, factors including husband's appropriate behavior, intimate relationship with family and no prior history of depression may reduce the incidence of postpartum depression