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Egyptian Journal of Pharmaceutical Sciences. 1992; 33 (3-4): 585-598
in English | IMEMR | ID: emr-23711

ABSTRACT

1 H-delta2-pyrazolines 2 were prepared from the reaction of 2- propen-1-ones 1 with hydrazine hydrate in absolute ethanol at room temperature. Reactions of 2 with acetyl, benzenesulphonyl-, p- toluenesulphonyl-chlorides and ethyl chloroformate gave the corresponding 1-substituted pyrazolines 3 and 4. Compounds 2 reacted also with different isocyanates and isothiocyanates to give carbanilides and thiocarbanilides 5. The pyrazoles 6 were obtained by reaction of the pyrazolines 2 with tetrachloro-O-benzoquinone


Subject(s)
Pharmacokinetics
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