ABSTRACT
The aim of the work was to evaluate the role of Tc-99m tetrofosmin in the assessment of the response of bone and soft tissue sarcomas to chemotherapy. In this study, 14 cases with histologically-proved osseous and soft tissue sarcomas were evaluated using Tc-99m tetrofosmin as an indicator of viable tumors for the assessment of chemotherapeutic induced response. Scanning was done at 10 minutes and 30 minutes after radiopharmaceutical injection with the calculation of tumor to non-tumor uptake ratios and retention indices. A significant correlation was found between the prechemotherapy 30 minutes tumor to non-tumor uptake ratio and the retention index of Tc-99m tetrofosmin as compared with the standard histologic grading of the chemotherapeutic effect. Moreover, post chemotherapy 10 minutes tumor to non-tumor uptake ratio was significantly correlated to such histologic grading. It was concluded that Tc-99m tetrofosmin is a good predictor of the tumor response to chemotherapy in osseous and soft tissue sarcomas
Subject(s)
Humans , Male , Female , Osteosarcoma , Drug Therapy , Technetium , Pathology , Treatment Outcome , Soft Tissue NeoplasmsABSTRACT
Twenty one Egyptian patients with gallstone disease have been randomly admitted at Ismailia General Hospital in 1993 and 1994. Cholecystectomy, and wedge liver biopsy were performed for every patient. Specimens were routinely processed in the Pathology Department, Faculty of Medicine, and sections were stained with hematoxylin and eosin, masson trichrome, and periodic acid schiff stains. The majority of patients were females with a mean age of 42.8 years. Histological examination of liver sections showed non-specific reactive changes in 11 cases [52.4%], chronic hepatitis with suggestion of virus C infection in 5 cases [23.8%], liver cirrhosis in 2 cases [9.5%], schistosomal infection in 2 cases [9.5%], and alcoholic-like hepatitis in one case [4.8%]. The findings were discussed and compared with those reported in the literature