clinical value of serum tumor-associated trypsin inhibitor tati in the diagnosis and follow-up of patients with gynecological tumors

To evaluate the serum levels and clinical value of TATI in different gynecological tumors, this study was carried out including 77 cases [40 with different types of gynecological cancer, 22 with benign diseases and 15 normal healthy controls]. Serum TATI was measured using radioimmunoassay [RIA] kit supplied by Farmos diagnostic. The results of the study showed that serum TATI was highly increased in the cancer group compared to either the group of benign diseases or the normal control group. At 100% specificity, TATI showed a sensitivity of about 60% in gynecological tumors as a whole and 73% in the endometrial, 50% in the ovarian and 60% in the cervical tumors. While at a lower specificity [60%], the sensitivity becomes 75% for the whole cancer patients, 91% in the endometrial, 64% in the ovarian and 60% in the cervical tumors. The benign cases showed a false positivity of about 32%. The follow up of certain cases after surgical interference showed that serum TATI is a valuable marker in monitoring these patients

Gamma-glutamyl transferase as a biochemical marker of endothelial damage in gestational hypertension

Gamma-glutamil transferase [GGT] and serum alkaline phosphatase, serum electrolytes and uric acid were measured in the study and control women. 13 women met strict criteria for the diagnosis of preeclampsia [PET], 7 women with gestational hypertension alone [PIH] and 20 normal pregnant women were selected from the same cohort and matched according to race, age, parity and gestational age [32-36 weeks]. There was a significant difference between the GGT concentration in PET [mean 27.3 +/- 1.65] and control [mean 15.76 +/- 0.721] women. Also, significant difference between PIH patients [mean 23.6 +/- 0.93] and control women. Uric acid concentration, serum sodium [S. Na] and serum potassium [S. K] concentrations differ significantly between PET patients [mean 3.9 +/- 0.34, 147 +/- 1.82, 4.64 +/- 0.18, respectively] and the control women [mean 2.52 +/- 0.216, 138.9 +/- 0.77, 4.1 +/- 0.04, respectively]. No significant difference was found in the concentration of S. uric acid, S. Na, S. K in the PIH patients and control women. It was found that, there is no difference in the serum alkaline phosphatase between either groups of gestational hypertension and the control group