ABSTRACT
To evaluate the prevalence of hypertension and diastolic dysfunction [LVDD] with normal ejection fraction in type-2 diabetes mellitus. Two hundred twelve diabetic patients [98 females and 114 males] from January 2005 to June 2006 were enrolled in this study. Their ages ranged from 35 to 65 years with mean age of 55 years. Patients with Diabetes Mellitus Type-2, Hypertension: BP[3]140/90 [with or without medication] Body Mass Index[3]30, Waist-Hip ratio>0.90. Left Ventricular Diastolic Dysfunction [LVDD] and Serum Triglyceride and HDL Cholesterol were included. Result: Out of 212 patients, 104[49%] were found to be hypertensive [both systolic and diastolic] and 12 patients [5.6%] were found to be suffering from isolated systolic hypertension. Hence total number of hypertensive patients was 116 [54.6%]. Thirty two patients were found to be suffering from diastolic dysfunction. Hypertension and Diabetes are interlinked and show how micro and macrovascular complications of diabetes are increased when two conditions occur together. The LVDD is much more prevalent than previously suggested in patients with type-2 diabetes mellitus. Hence LVDD is an early marker of diabetic cardiomyopathy
ABSTRACT
To find out the prevalence of metabolic syndrome in type-2 Diabetes Mellitus and its cardiovascular affects using the guide lines of WHO [World Health Organization] and NCEP [National Cholesterol Education Program]. Six hundred eighty patients were selected on a random sample basis from those suffering from Diabetes Mellitus Type-2 from January 2004 to May 2005, at the Ziauddin Medical University Hospital and Consultation Clinic. Six hundred eighty patients were screened and their mean age was 58 years with 374 [55%] being males and 306 [45%] being females. Their mean duration of Diabetes Mellitus was observed to be 13 years. Three hundred twelve [46%] were found to be of Metabolic Syndrome. Out of this 143 were found to have cardiovascular events. Early diagnosis, treatment and prevention of Diabetes Mellitus Type-2 and Metabolic Syndrome present a major challenge for health care professional facing an epidemic of over-weight and sedentary life-style