Synthesis and insecticidal activity of bis 4, 4-[2-substituted aryl thiazolidine-4-one] diphenyl sulphone

A series of thiazolidine-4-one have been synthesized by condensation of 4, 4-diaminodiphenyi sulphone with four different substituted aromatic aldehydes to yield the Schiff s bases. Cyclocondensation of Schiff s bases with thioglycolic acid afforded Bis 4, 4-[2-substituted aryl thiazolidine-4-one] diphenyi sulphone. The structure of newly synthesized compounds were confirmed using analytical and spectral [IR and PNMR] data. All these compounds were evaluated for their insecticidal activity. All four compounds have equipotent insecticidal activity with the standard drug Cypermethrin

Synthesis of some new 3-[3-[4'-methoxy benzenesulfonamido] phenyl]-5-[substituted phenyl]-2-pyrazolines, its derivatives and anthelmintic activity

The compounds containing heterocyclic moiety played an important role in the field of medicine and agriculture. It makes possible research upgrading the synthesis, modification and changes in structure of heterocyclic compounds. The pyrazolines have their own importance in heterocyclic compounds due to valuable biological activities. The chemistry of chalcones has generated a lot of scientific studies with special reference to biological applications such as anti-ulcer, antitumour, antitubercular, antidepressant and fungicidal activities. Literature survey indicates that pyrazolines have not been prepared from sulfamino and ethereal linkaging containing chalcones. In the present work para-methoxy benzenesulphonil chloride reacts with metaminoacetophenone to form 3[4'-methoxybenzenesulfonamido] acetophenone [I]. In second step acetophenone [I] reacts with different aromatic aldehyde to form chalcones [II a-c]. In third step chalcones are cyclized with hydrazine hydrate, phenylhydrazine and 2,4-dinitrophenyl hydrazine to form new substituted-2-pyrazolinesI[1-16]. The structures of newly synthesized compounds are confirmed by elemental analysis, IR and p-NMR spectral studies. The synthesized compounds are screened for their anthelmintic activity

Synthesis and antimicrobial activity study of new-1-carboxamido-3-[-4-naphthyl sulphonamidophenyl]-5-aryl substituted 2-pyrazoline

In view of potential biological activity of pyrazoline[1-4] it was considered worth while to synthesize some new-1-carboxamido-3-[-4-naphthyl sulphonamido-phenyl]-5-aryl-substituted-2-pyrazoline by the action of semicarbazidehydro-chloride with 1-[3-naphthyl sulphonamidophenyl]-3-aryl prop-2-ene-1-one [1a-d] in basic medium. The synthesized compounds have been characterized by elemental analysis, I.R. and [1]H-NMR spectra analysis and screened for antimicrobial activity