High energy states of tolnaftate

Solid dispersions of tolnaftate were prepared using polyvinylpyrrolidone [PVP], polyethylene glycol 20,000 [PEG], urea, thiourea, sucrose and glucose. The dissolution studies showed that the presence of water soluble polymers enhance the dissolution rate of the drug. The amount of tolnaftate released after three hours increased more than 33 times and 25 times on using PVP and PEG respectively as compared with the dissolution of the control untreated powder. The solid dispersion systems were examined using differential thermal analysis [DTA] and showed a reaction at higher temperature only. The dissolution rate was also increased in presence of surface active agent. This may be due to better wetting of the power in the solution presumably lower surface tension. The effect of the used polymers and surfactants on the solubility of tolnaftate was also investigated

Molecular compounds of 1-hydrazinophthalazine hydrochloride with aromatic di- and tri- nitro compounds Preparation and infrared spectroscopic investigation

Molecular complexes of 1-hydrazinophthalazine with some aromatic nitro compounds are prepared and investigated applying IR and electronic absorption spectroscopy. The results revealed that complex formation takes place only through pi-electron transfer in case of non-acidic and weak acidic acceptors. With strong acidic acceptors the reaction occurs through both electron and proton transfer; the phthalazine ring being the moiety involved in the reaction. The charge transfer energies for some of the complexes are calculated from the electronic absorption spectra

Spectrophotometric studies on the Al, Ga and in chelates with 5- [2-hydroxy-5-sulphophenylazo] -8-quinolinol

Trivalent ions of Al, Ga and In form colored complexes with 5 - [2-, hydroxy - 5-8 sulphaphenylazo] -8- quinolinol. The complexes were used satisfactorily for the photometric determination of the metal ions. The optimum conditions for the formation of the complexes were extensively investigated. Universal buffers of pH 6.6, 4.5 and 6.60 were used for Al, Ga and In respectively. The stoichiometry of the formed complexes and their stability constants were determined spectrophotometrically. The interference of many metal ions in the determination was also investigated. Beer's law is obeyed up to 0.67, 1.7 and 3.44 ppm metal ion. A Spectrophotometric titration of Ga with EDTA proved to be successful