Oltipraz treatment in experimental schistosomiasis mansoni: I morphological changes among S mansoni worms induced by high dose oral therapy in mice

Worms recovered from Oltiparz treated group of mice [500 mg/kg. body weight] show, stunted ness, absent or poorly developed tuberculations, destroyed or poorly developed suckers, absence or severe atrophy of testes, complete absence or severe atrophy of ovaries, small or empty vitelline follicles and slightly or not pigmented intestines as compared with controls; the female worms are more affected than males. The morphological changes are apparent after 5 days, 7 days, 20 days and 30 days from drug administration, but are reversible in some surviving worms especially male worms after 60 days from therapy. The previous findings indicate that the drug causes severe degenerative changes in the structure of both S. mansoni male and female worms and that resistance to the drug develops among the Egyptian strain of S. mansoni worms with prolongation the period of worms exposure to the drug. The present results are discussed with those of others with some recommendations

Oltipraz treatment in experimental schistosomiasis mansoni II effect of high dose oral therapy on worm load and process of copulation in infected mice

A single oral dose of 500 mg/kg body weight of Oltipraz was given to mice experimentally infected with the Egyptian strain of S. mansoni. The drug caused significant reduction in the number of worms and marked reduction in the percentage of paired worms in comparison to the infected untreated controls. This reduction in number was apparent after 5 days, 7 days and 2 days from Oltipraz administration, then the number gradually increased with elapsed time till the 60th day after therapy [the end of the work]. The previous findings might indicate development of resistance to Oltipraz among the Egyptian strain of S. mansoni worms with prolongation the period of worms exposure to the drug

Oltipraz treatment in experimental schistosomiasis mansoni: III effect of high dose oral therapy on hepatic shift of worms and tissue bould ova pattern in infected mice

Oltipraz was given in a single oral dose of 500 mg/kg body weight to mice experimentally infected with the Egyptian strain of S. mansoni. The drug caused marked hepatic shift of the worms in comparison to the infected untreated controls. Hepatic shift of worms was apparent till the 30th day from Oltipraz administration, while pronounced back shift to mesenteric veins by the surviving parasites occurred 60 days post- treatment. The drug also caused death of all bilharzial eggs located inside tissues of the small intestines of infected mice and complete eradication of fecal eggs after the 5th, 7th, 20th, 30th and 60th days from therapy. These findings need the histopathological investigations