ABSTRACT
Toxicological and toxicogenetic effects of aqueous (tea) and hexanica fruit extract of Indigofera suffruticosa Mill, and hydroalcoholic root extract od Solanum agrarium Stendt. Were evaluated in Balb C male mice intraperitoneally exposed. A hepatotoxic effect was observed just for animals treated with aqueous fruit extract of I. suffruticosa. In relation to the toxicogenetic effect, just the group trreated with 12.5% of toxic dose of aqueous fruit extract of I. suffruticosa showed a statistically significant increase in the frequency of cells with chromosome aberrations (cytogenetic effect), although a slight increase was also observed for the highest dose (25% of LF50_ of hydroalcoholic root extract of S. agrarium. The results obtanied show that before S. agrarium is used as medicine and before the wide use of I. suffruticosa in cattle food, careful evaluation must be done.
Subject(s)
Animals , Mice , Plants, Medicinal/poisoning , Plant Extracts/isolation & purification , Animal Feed/toxicity , Brazil , Chromosome Aberrations , Lethal Dose 50 , Mice, Inbred BALB CABSTRACT
O efeito de 4 inseticidas organofosforados (malation, diazinon, diclorvos e triclorfon) foi avaliado em camundongos, através do teste de morfologia de espermatozóide. Os animais foram expostos aos inseticidas, por via intraperitoneal (diazinon, diclorvos e triclorfon), via dérmica (malation) e por inalaçäo (diclorvos) durante 5 dias consecutivos. Um aumento significativo na frequência de espermatozóides anômalos foi observado quando os animais foram expostos ao malation (1000 mg/Kg) ao diazinon (100 mg/Kg) e ao diclorvos, por inalaçäo (0,24 e 0,32 mg/l). Contudo, nenhum aumento significativo foi observado com relaçäo ao triclorfon e ao diclorvos quando os animais foram expostos pro via intraperitoneal