Gastric pull-up after total pharyngolaryngectomy

In this study, 50 patients with hypopharyngeal carcinoma underwent gastric pull-up following total laryngopharyngectomy. The postoperative mortality was 10% and the postoperative morbidity was mainly due to pleural injury, hemorrhage, minor fistulae and mediastinitis. It was found that fistulae occurred in 16% of the cases, hemorrhage in 4% and abdominal wound dehiscence in 4%. The perioperative mortality was 10% in the cases

role of CA15.3 in cancer breast and its correlation with some other tumour markers

The aim of this study was to evaluate serum tumor markers [CA15-3, CEA and TNF] and ER receptors in serum and urine. It was done on 20 patients with breast cancer, 20 patients with benign breast lesions and 20 normal controls. A significant high level of the mean serum value of CA15-3 in cancer patients compared with benign and control groups. The mean preoperative levels returned nearly to normal in completely cured cases, while it was in a high level if there was metastasis or recurrence. In conclusion, serum CA15-3 and CEA levels could be valuable as a prognostic parameter and may have a role in monitoring patients with breast cancer. Other tested tumor markers, especially TNF may be complementary in this regard, while receptor patterns were important for determining the modality and response of treatment

Increased tumor necrosis factor [TNF] level in patients with bronchogenic carcinoma with higher values in patients with bone marrow metastasis

TNF is a protein produced by various cell types, mainly monocytes, and has been originally shown to induce necrosis of tumors in vivo. Serum TNF-alpha levels were demonstrated by radioimmunoassay in 17 patients with bronchogenic carcinoma [9 cases with small cell carcinoma and 8 with squamous cell carcinoma]. TNF level was significantly increased in 14 patients [65 +/- 12 ng/L] in comparison with the control group [19 +/- 6 ng/L]. The highest TNF level was encountered in patients with small cell carcinoma, especially in those with bone marrow metastasis [3 cases]. The variation in the TNF level may be due to a variation in immunogenicity of different pathological types or a variation in the TNF receptor numbers of affinity on different cell types. TNF may have a role in the progress of the disease and the bone marrow Involvement

Local facial flaps for reconstruction of post-resectional facial defects in basal cell carcinoma

This study includes 60 cases with Basal Cell Carcinoma [BCC] of the face. They are 37 males and 23 females, with average age 58 years. There are 26 cases with BCC of the cheek, 26 cases with BCC of the nose, 5 cases with BCC of the lip and 3 cases with BCC of the forehead. The repair of the defect after surgical excision of the lesion with adequate safety margin was done as follow: nasolabial flap in 20 cases. local cheek flap in 16 cases, glabellar and forehead flap in 10 cases, advancement in 4 cases, Kite flap in 6 cases and double flaps in 4 cases. There are minimal complications such as haemorrhage in 2 cases, infection in 2 cases, partial dehiscence in 3 cases, partial necrosis in 4 cases, deformity in 2 cases and tumor recurrence in 2 cases. The aesthetic results were excellent in 20 cases, good in 32 cases, moderate in 6 cases and poor in 2 cases