Comparison between Conventional and Modified Superficial Liposuction Techniques in the Treatment of Axillary Osmidrosis / 대한피부과학회지

BACKGROUND: Axillary osmidrosis is caused by abnormal apocrine glands. Although various treatment modalities have been developed for axillary osmidrosis, there have not been sufficient studies to establish a treatment guideline. OBJECTIVE: This study aimed to evaluate the efficacy, safety, and disease recurrence rate of treatment by superficial liposuction with dermal curettage using Fatemi cannula to the level of the dermal-subcutaneous junction (modified technique) compared to dermal curettage to the level of the mid-dermis (conventional technique). METHODS: Fifty-two patients (104 axillae) underwent the modified technique and 54 patients (108 axillae) underwent the conventional technique from April 2007 to September 2014. The patients' demographic data, clinical efficacy of each treatment as evaluated using subjective satisfaction scales, postoperative complications, and recurrence rates were retrospectively reviewed, and procedures compared. RESULTS: Excellent to good outcomes were reported in 46 patients (88.5%) who underwent the modified technique and 50 patients (92.6%) who underwent the conventional technique. Recurrence occurred in 12.5% (13/104) of axillae in patients who underwent the modified technique, and 9.3% (10/108) of axillae in patients who underwent the conventional technique. There was no statistically significant difference in clinical efficacy, safety, or recurrence rates between the two techniques (p>0.05). Skin necrosis was significantly lower using the modified technique (p=0.017). CONCLUSION: Our study found that clinical results of the modified technique were comparable with those of the conventional technique. The modified technique is a convenient treatment for axillary osmidrosis, with high efficacy and low disease recurrence.

Effects of a Silkworm Extract on Dopamine and Monoamine Oxidase-B Activity in an MPTP-induced Parkinsons Disease Model / 한국실험동물학회지

The protective efficacy of a silkworm extract (SE) on N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism and its possible mechanisms were studied in C57BL/6 mice. Mice were administrated intraperitoneally with SE (20 mg/kg/day) for 15 days and MPTP (10 mg/kg/day) was administrated subcutaneously into the mice for the first 6 consecutive days 1 hour before SE treatment. All animals were sacrificed 24 hours after the last SE treatment. Then the parameters related to general toxicity and neurobiochemical markers, such as the dopamine level and the activities of monoamine oxidase (MAO)-B, were measured in various regions of the brain. Treatment of mice with SE effectively attenuated the MPTP-induced decline of striatal dopamine level. MAO-B activity in SE-pretreated mice was inhibited in whole brain, cerebellum and substantia nigra. These results suggest that SE plays an effective role in attenuating MPTP-induced neurotoxicity in animal model. These neuroprotective effects of SE are likely the result from the inhibitory effect on MAO-B activity in mouse brain.

Effects of a Silkworm Extract on Dopamine and Monoamine Oxidase-B Activity in an MPTP-induced Parkinsons Disease Model / 한국실험동물학회지

The protective efficacy of a silkworm extract (SE) on N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism and its possible mechanisms were studied in C57BL/6 mice. Mice were administrated intraperitoneally with SE (20 mg/kg/day) for 15 days and MPTP (10 mg/kg/day) was administrated subcutaneously into the mice for the first 6 consecutive days 1 hour before SE treatment. All animals were sacrificed 24 hours after the last SE treatment. Then the parameters related to general toxicity and neurobiochemical markers, such as the dopamine level and the activities of monoamine oxidase (MAO)-B, were measured in various regions of the brain. Treatment of mice with SE effectively attenuated the MPTP-induced decline of striatal dopamine level. MAO-B activity in SE-pretreated mice was inhibited in whole brain, cerebellum and substantia nigra. These results suggest that SE plays an effective role in attenuating MPTP-induced neurotoxicity in animal model. These neuroprotective effects of SE are likely the result from the inhibitory effect on MAO-B activity in mouse brain.

Hypoxic Hepatitis in a Postresuscitation State

PURPOSE: Hypoxic hepatitis is also known as ischemic hepatitis, and this is believed to be the result of a reduction in systemic blood flow, as typically occurs in patients suffering with shock. The previous reports on hypoxic hepatitis didn't focused on the postresuscitation state. The aim of this study was to investigate the incidence, survival rate and predisposing factors of hypoxic hepatitis in the postresuscitation state. METHODS: We retrospectively analyzed the medical records of 94 patients who were in a postresuscitation state for more than 72 hours with nontraumatic cardiopulmonary arrest and they had been admitted to our university hospital between April 1997 and May 2007. The patients were divided into two groups: the hypoxic hepatitis group (HH) vs the non-hypoxic hepatitis group (Non-HH). RESULTS: Hypoxic hepatitis was identified in about 37% of the patients who survived for at least 72 hours in a postresuscitation state. Hypoxic hepatitis was significantly related to gender, the duration of resuscitation, the cumulative epinephrine dose and the cause of arrest. In addition, the underlying diseases such as baseline renal insufficiency, hypertension and coronary artery disease were related to hypoxic hepatitis. CONCLUSION: Hypoxic hepatitis is a common condition in postresuscitation patients. The prognosis of hypoxic hepatitis is benign in the postresuscitation state. There was no correlation between hypoxic hepatitis and the survival rate.

A Case of Squamous Cell Carcinoma Metastasized from Esophageal Carcinoma / 대한피부과학회지

We report a case of squamous cell carcinoma originating from esophageal carcinoma. 2 X 3cm sized, flesh-colored, soft, movable nodules were detected on the scalp in a 59-year-old man. He was made a diagnosis of squamous cell carcinoma in the distal esophagus a year ago. Histopathologic examination showed that the tumor had multiple mitoses and horn pearls, but there was no connection between the epidermis and the tumor nests. In immunohistochemical stains, cytokeratin- high molecular weight and EMA was positive, but CEA was negative.

Use of Alternative Medicine by Patients with Psoriasis

BACKGROUND: Psoriasis is a disabling and intractable disease influencing the psychosocial life of the patients. Patients who are frustrated with orthodox medicine may explore alternative therapies. OBJECTIVE: This study was done to research on the actual condition of the use of alternative medicine in the patients with psoriasis. METHODS: A self-administered questionnaire was constructed, and was given to the patients to answer our questions. RESULTS: Among 128 patients with psoriasis, 61 (47.7%) reported previous use of one or more forms of alternative medicine. The absence of satisfactory long-term effects of physician-provided therapy was the main reason for patients trying alternative medicine. Persons without skin s disease and the mass media were the main sources of information on alternative medicine. CONCLUSION: Alternative therapies were widely utilized by subjects participating in this study, and dermatologists need to be aware of alternative treatments employed by their patients.

Correlations Between HLA-Cw*0602 and Clinical Picture in Korean Psoriatic Patients / 대한피부과학회지

BACKGROUND: HLA-Cw6 has the strongest individual association with psoriasis in many racial groups, and associations with the positive family history and early age at onset have been noted in many studies. OBJECTIVE: The aim of this study was to investigate whether Cw6 correlate with the clinical parameters of Korean psoriatic patients. METHODS: One hundred and twelve unrelated patients with psoriasis, and 166 healthy controls were examined with regard to Cw*0602, using a PCR-SSP method. We divided the patients into two groups according to Cw*0602 positivity, and compared two groups with reference to several clinical parameters. RESULTS: The results are summarized as follows: 1. Cw*0602 was found in 69.6% of the 112 patients, but only in 9.0% of the 166 healthy controls(p<0.05, RR=23.1). 2. The presence of Cw*0602 correlated with early age at onset(26.1 vs. 32.5 years, p<0.05), and Cw*0602 was present in 75.0% of the patients with early onset(p<0.05, RR=30.2). 3. The presence of Cw*0602 did not correlate with a positive family history of psoriasis among the first-degree relatives, but correlated with an overall positive family history (p<0.05). 4. There were no positive correlations with arthritis, the history of inpatient treatment, the clinical type of psoriasis, and onset or exacerbation after upper respiratory infection. CONCLUSION: The presence of Cw*0602 correlated with a positive family history for psoriasis and early age at onset, but did not correlate with arthritis, the history of inpatient treatment, the clinical type of psoriasis, and onset or exacerbation after upper respiratory infection.

A Case of Cutis Marmorata Telangiectatica Congenita / 대한피부과학회지

We experienced a case of cutis marmorata telangiectatica congenita in a 2-year-old girl. The patient had reddish to violet reticulated patches with telangiectasia on the left leg and left side of trunk since birth. The circumference of the affected leg was decreased. No other associated anomalies were found on physical and X-ray examinations. The skin biopsy revealed dilatation and proliferation of capillaries with mild perivascular inflammatory cell infiltration in all layers of the dermis and subcutaneous fat.

A Case of Sebaceous Epithelioma / 대한피부과학회지

We report a case of sebaceous epithelioma developed on the scalp of a 55-year-old man. Histopathologic examination revealed irregularly shaped cell aggregates partially connecting to the overlying epidermis. The majority of cells were undifferentiated basaloid cells, but some cells were sebaceous cells or transitional cells.

A Case of NCAM-positive Nasal Type T/NK-Cell Lymphoma

We herein report a case of nasal type T/natural killer(NK)-cell lymphoma(TNKCL). This lymphoma is characterized by the expression of CD2, CD43 and NCAM(CD56) antigen, an aggressive clinical course, frequent extranodal spreading, a strong association with Epstein-Barr virus(EBV), and the absence of T-cell receptor(TCR) gene rearrangement. NCAM antigen is known to be a possible determinant of extranodal dissemination of peripheral T-cell lymphoma(PTCL). The patient is a 70-year-old male with skin lesion on his forearm. Histopathological and immunohistochemical studies were diagnostic of EBV-associated TNKCL. Untill now, he has failed to respond to anticancer therapy.

A Case of Silicone Granuloma After Liquid Silicone Injection / 대한피부과학회지

We report a case of silicone granuloma of the breast in a 38-year-old female patient who had been injected with liquid silicone by an unauthorized practitioner for augmentation of her breast. On histopathological examination, we could observe numerous variable sized ovoid or round cavities that gave the section a ""Swiss cheese"" appearance in the dermis and subcutaneous fat. She was treated initially with oral antibiotics and corticosteroids with no significant improvement, and she was referred to the Plastic Surgery Department for surgical removal of the silicone granuloma.

Two Cases of the Angioimmunoblastic Lymphadenopathy Type of Peripheral T - cell Lymphoma : Different Clinical Courses According to Positivity to Epstein-Barr Virus

Peripheral T-cel1 lymphoma(PTCL) encompasses histopathologically and clinically various spectra of cutaneous T-cell lymphoma(CTCL). In this report, we describe two cases of PTCL showing diRerent clinical courses according to EBV(Epstein-Barr virus) positivity. The chnical course of case 1 with EBV-associated PTCL was rapidby fatal and refractory to intensive chcmotherapy. However, in case 2, EBV genomes were not found in her lesional tissues and she showed an indolent clinical course withoaat systemic symptoms. Accordingly, serological and immunohistochemical investigations for EBV might be mandatory in cutaneous PTCL to evaluate clinical prognosis.

A Case of Secondary Cutaneous Diffuse Large B-cell Lymphoma

We herein report a case of secondary cutaneous diffuse large B-cell lymphoma(DLBCL) occurring in a 66-year-old woman. The skin lesions were erythematous infiltrative nodules on the right inguinal area. Histologically, the skin lesion disclosed DLBCL mainly composed of immunoblasts. Concurrently, she showed lymph node involvement. Initially, however, we could not define the conclusive temporal sequences between nodal lesions and skin lesions. Finally, additional further studies revealed this case as secondary cutaneous 8-cell lymphoma, and she was managed with systemic chemotherapy.

A Case of Non-T,Non-B Primary Cutaneous Lymphoblastic Lymphoma

We herein present a case of a 2-year-old girl with non-Hodgkin's lymphoma(NHL) of the lymphoblastic type involving cutaneous sites at the time of diagnosis. The histological finding was typical of lymphoblastic lymphoma. However, immunophenotypically, this lymphoma was not of the T-cell or B-cell type, although the vast majority of lymphoblastic lymphomas involving the skin are usually of the pre-B cell or T-ce11 type. Until now, there have been few reports of non-T, non-B primary cutaneous lymphoblastic lymphoma expressing surface CD10 and CD56 antigens as in this case.