ABSTRACT
Chronic Hepatitis C virus (HCV) infection is a major public health problem. It is a major cause for cirrhosis and hepatocellular carcinoma worldwide. HCV infection is recognized now days as a disease of global importance. It is considered a major health and economic burden in adults as well as children in both developing and developed countries. Objectives: To study the Clinical presentation, biochemical profile and risk factor of chronic hepatitis C virus infected patients. Methods: This prospective observational study was carried out in the Department of Medicine at STH, Haldwani, from August 2016 to July 2018.During these study period 110 patients with Chronic HCV infection were analyzed. Results: Out of 110 patients 60 (54.54%) were male and 50(45.45%) were female. Injection drug use (IDU) was the most common risk factor of HCV infection (20.90%). The abdominal discomfort symptoms seen in majority of patients (70%) followed by a fatigue (62.72%).and fever (60.90%). Males exhibiting more symptoms in comparison to females. Conclusion: Viral hepatitis is an important heath care problem in India as it occurs epidemically and sporadically. The variability in nature of the disease regarding its onset, presenting symptoms, clinical course and development of complications are important aspects. So, it is very essential for health care professionals to be aware of all aspects of it so that it is detected and treated early.
ABSTRACT
ackground: HBV is one of the main causes of end stage liver disease and hepatocellular carcinoma (HCC). The clinical presentation ranges from asymptomatic or inapparent infection to acute liver failure. Chronic liver disease with cirrhosis and hepato-cellular carcinoma are the other spectrum of the disease. Method: All the patients diagnosed with hepatitis B surface antigen (HBs Ag Positive) presenting with or without symptoms and signs of hepatitis B infection were included in study. Result: The age of the patients varied from 15-75 years. 60% patients are male, majority (55.5%) are married, 40% are secondary educated, 47% are labour class, 69% of patients having unknown sources of infection. Majority of patients were presented with symptoms and only 27% were asymotomatic on presentation. Major symptom were abdominal discomfort, fever and fatigue. 65% patients having icterus, 55.5% hepatomegaly and 35% patients having no any clinical signs. Serum bilirubin and alanine transaminase (ALT) level were significantly higher in symptomatic patients (60%). 13% patients shows portal hypertention and 22% shows ascites on ultrasonography. Conclussion: The majority (65.45%) of patients were in younger age group 15-45 years, majority are male(60%), married (55.5%), labour class (47.3%) .The risk factor as related to HBsAg positivity was because of unknown source 76 (69.09%) cases followed by history of previous surgery 14 (12.7%) cases