ABSTRACT
Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss [RPL] in the Iranian population. We aimed to evaluate the precise association between thrombophilic genes polymorphisms [MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G] and RPL risk in the Iranian population. PubMed, Web of Science, Google Scholar, and ISC were searched for eligible articles published up to April 1, 2017. In total, 37 case-control studies in 18 relevant publications were selected: 1,199, 1,194, 630, 830, and 955 RPL cases and 1,079, 1079, 594, 794, and 499 controls for MTHFR C677T, MTHFR A1298C,Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G, respectively. The results indicated a significant increased risk of RPL in all genetic models in the population. Also, Prothrombin G20210A and FVL G1691A as well as PAI-1 4G/5G polymorphisms were associated with RPL risk in the Iranian population. Hence, thrombophilic genes polymorphisms are associated with an increased RPL risk in the Iranian population
Subject(s)
Humans , Female , Thrombophilia/genetics , Prothrombin , Polymorphism, GeneticABSTRACT
The aim of this investigation was conducted to proteomic analysis of plasma obtained from pregnant women who destined to develop late-onset preeclampsia without intrauterine growth restriction [IUGR] during 16[th] week of gestation. Plasma was obtained from primiparous women during 16[th] week of gestation. 2-DE proteomic analysis was done for plasma from 11 healthy pregnant women and 11 women who developed preeclampsia later. Using bioinformatic analysis with Progenesis SameSpots ver4.0 software and ANOVA test, expression of 2 spots were statistically different between two groups. In preeclamptic state, expression of both were decreased, one of these spots was vitamin D binding protein [p-value: 0.047], the other one will be discussed in another paper. According to results, we concluded that during 16[th] week of gestation, occurance of late-onset preeclampsia without IUGR is predictable. During this week, pathology of disease is present and may be the process of placental degeneration and impaired placentation are include in disease pathology
ABSTRACT
Objective: This study was conducted with the aim to investigate and compare Iranian produced and foreign oxytocin for use in induction of labor
Materials and methods: This random clinical trial was conducted on a population of 198 pregnant women with live fetus and cephalic presentation and conditions conducive to induction of labor, monitored by obstetricians and gynecologists. They were randomly divided into group A [n = 99] received 10 units of Syntocinon [Novartis Pharma Canada] in 500 cc Ringer lactate, and group B [n = 99] received 10 units of Oxytip [Caspian Tamin Company Iran] in 500 cc serum, who entered the study to commence induction, by signing written consent. Study variables such as induction indications [post-term, ruptured membranes, diabetes, and..], induction duration, duration of the 1[st] and the 2[nd] stages of labor, and delivery method; as well as labor outcomes like hyper-stimulation of uterine, postpartum bleeding, 5-minute Apgar score, and infant's birth weight; and neonatal outcomes [admission to NICU, oxygen and intubation] were assessed for the two groups by a trained midwife and registered in the patient's questionnaire. Data were analyzed in SPSS software using statistical tests: t-test, Chi-square, and Mann-Whitney
Results: Two groups were similar in demographic variables such as; age, BMI, parity, education. There was no significant difference regarding to obstetric and gynecologic characteristics such as: gestational age, dilatation, effacement, and fetal positioning, as well as the indication for labor induction when the study began. After intervention, variables including: induction duration, duration of the 1[st] and the 2[nd] stages of labor, delivery method; and labor outcomes such as: hyper-stimulation of uterine, postpartum bleeding, 5-minute Apgar score, and infant's birth weight; and neonatal outcomes [admission to NICU, oxygen and intubation], in the two groups, were found to be the same [P < 0.05]. Mean oxytip dosage needed was less than that of oxytocin to reach for appropriate pain [P = 0.042]
Conclusion: The two drugs in terms of labor induction and neonatal complications had similar outcomes and the locally made drug with a lower dosage appears to produce the desired outcome
ABSTRACT
The possible effect of iron supplementation has been investigated in the normal population and patients with gestational diabetes mellitus [GDM]. In this study, we survey the risk factors of GDM in pregnant women in contrast with normoglycemic patients in a case control study in patients using iron supplement. This case control study conducted on 52 pregnant women with GDM [25 women with type Al and 27 women with Type A2 of GDM]. The control group randomly selected 50 normoglycemic women. Venous blood sampling was done between 24 and 28 weeks of pregnancy for measuring of ferritin, lipoproteins, uric acid and malondialdehyde serum levels. Under study variables including age, gestational age, weight and BMI were gathered. All the women were followed up until the time of delivery and pregnancy outcome were gathered. The serum ferritin levels in GDM group was 31.22+15.44, which is significantly higher than 24.76+8.94, in the control group with [P=0.012]. Plasma hemogulobin in the control group was 12.2+0.1 compared to 12.9+0.1 in GDM group which was significantly lower [P=0.005]. Triglycerides was significantly higher in GDM group in contrast with the control group, 275.08+143.17 and 192.30+92.13 [P=0.001], respectively. Finally, our findings indicate the concentration of serum ferritin levels was significantly higher in The GDM group
ABSTRACT
There are strong evidences suggesting the secretion of different cytokines in cervical fluid during preterm labor. Betamethasone is widely administered for several reasons in preterm conditions. To Investigate the possible effect of betamethasone on endocervical cytokine concentration of women at risk of preterm labor. In a randomized clinical trial of 80 prime-gravid women in preterm labor between 34 and 37 weeks of gestation, cervical fluid was collected. Endocervical concentration of inflammatory cytokines were analyzed before and 48 hours after betamethasone treatment for the evaluation of IL-8, IL-17, IFN-gamma and TGF-beta. Wilcoxon and Mann-Whitney tests were employed for statistical analysis. chi2 and Student's t tests were used whenever needed. All the measured cytokines showed significant changes in the betamethasone treated group. IL-17 [p=0.001], IL-8 [p=0.001], and IFN- gamma [p<0.05] decreased significantly, while TGF-beta had a significant increase [p<0.05]. In the patients who delivered before or on the 7[th] day of admission, IL-17, IL-8, and IFN-gamma levels were all significantly higher. However, TGF-beta decreased significantly in the same samples in the betamethasone treated group [p<0.05]. Betamethasone significantly decreases the endocervical pro-inflammatory cytokine oncentrations in patients with preterm labor.
ABSTRACT
Pregnancy is a physiological condition that its concurrence with fasting introduces some controversies about condition of mother and fetus. This study was conducted to evaluate the effect of fasting on pregnancy outcome. The historical cohort paradigm of this study was conducted on referrals of one of the Tehran's hospitals in 2004. All pregnant women at one of the trimesters in holy month of Ramadan were included in the study. The women were divided into non-fasting, 1-10 days I fasting, 11-20 days fasting, and 21-30 days fasting. For statistical analysis of data, covariance analysis and SPSS package was used. Findings: In this study, 189 cases were evaluated and their mean age, weight, and body mass index [BMI] were 25.9 years, 61.7 kg, and 23.9 kg/m[2] respectively. The mean for number of days on fasting was 13 days and 66 cases [34.9%] had not been on fasting. In addition, there was no significant difference between BMI at the beginning of pregnancy, mother's age, number of pregnancies, and a history of abortion in different groups. Meanwhile, there was also no significant difference between means of weight, height, and head circumference of infants with number of days on fasting. Furthermore, there was no significant difference between pregnancy outcome parameters and fasting at different trimesters. According to these findings, in healthy women with appropriate nutrition, Islamic fasting has no inappropriate effect on intrauterine growth and birth-time indices. Meanwhile, relative risk of low weight birth was 1.5 times in mothers on fasting at first trimester as compared to non-fasting mothers