Interaction of Magnesium Sulfate with Mivacurium-induced Neuromuscular Block in Rabbits / 대한마취과학회지

BACKGROUND: Magnesium sulfate(MgSO4) has long been used in the treatment of pre-eclampsia and hypertension. Mivacurium was found to undergo hydrolysis by plasma cholinesterase at 70-88% of the rate of succinylcholine. This study has been conducted to evaluate the time course of mivacurium-induced neuromuscular block according to the pretreatment doses of MgSO4 in rabbits. METHODS: This study was done using a common peroneal nerve-anterior tibialis muscle preparation in sixty adult rabbits. The onset and recovery times of mivacurium(0.16 mg/kg) were evaluated after the infusion of a placebo in group 1, MgSO4 30 mg/kg in group 2, MgSO4 50 mg/kg in group 3 and MgSO4 70 mg/kg in group 4, respectively(n=15 each). RESULTS: The mean serum concentration of magnesium was 2.4 mEq/L in group 1, 3.3 mEq/L in group 2, 4.3 mEq/L in group 3 and 5.5 mEq/L in group 4, respectively. The mean time from injection of mivacurium to 95% recovery of twitch amplitude was 32.7 min. in group 1, 32.9 min. in group 2, 30.4 min. in group 3 and 33.0 min. in group 4, respectively. CONCLUSIONS: The results of the present study suggested that the neuromuscular blocking actions of mivacurium are not affected according to the pretreatment doses of MgSO4.

Assessment of Temperature and Humidity in Operating Room, Recovery Room and Intensive Care Unit / 대한마취과학회지

It is recognized that there may be numerous medical hazards associated with the maintenance of relative humidity below 50 percent. These include the danger of producing hypothermia in patients, especially during long operative procedures; the fact that floating particulate matter increased in conditions of low relative humidity, and the fact that the incidence of wound infections is minimized following procedures performed in those operating rooms in which the relative humidity is maintained at the level of 50 to 55 percent. So, we have checked room temperature and relative humidity of operating theater in Hanyang University Hospital during 1 year from January, 1991. The results were as following; 1) Room temperature wae maintained at the level of 23.6+/-0.8 to 27.7+/-1.3 degrees C, and it was somewhat lower in shadowy rooms than in sunny ones. 2) Relative humidity was highest level in July, and it was maintaiaed at the level of 41.7+/-4.9 to 47.0+/-7.7%. Generally, it was decreased unsignificantly in order of ICU, recovery room, newbuilt shadowy rooms, old shadowy rooms, and sunny rooms. 3) Relative humidity was significantly decreased to 2.4+/-3.8-28.9+/-5.0% in spring, autumn, and winter. 4) Absolute humidity was maintained at the level of 11.6+/-1.7 mgH2O/L in summer, and l.l+/-1.4 mgH2O/L in winter. With above results, we recognized that room temperature of operating theater was maintained at the level of recommending degree, but relative humidity(percent) was too low to be suitable for operation and/or special patient care. This means that ventilation of operating theatre should be installed with proper temperature and relative humidity controlled units.

Wolff-Parkinson-White Syndrome And Epidural Inhalation Anesthesia - A case report / 대한마취과학회지

The Wolff-Parkinson-White syndrome (WPW syndrome) and its variants are called the preexcitation syndrome. Anesthetic management of the patient with WPW syndrome requires the minimizing or avoidance of tachyarrythmias. Various anesthetic plans are employed for this purpose. For example, N2O, oxygen and narcotic technique, neuroleptanalgesia, deep inhalation anesthesia are included in this category. We have recently anesthetized a patient with preexcitation syndrome, performing continuous epidural anesthesia with 2% lidocaine and single bolus injection of Innovar followed by general endotracheal inhalation anesthesia with enflurane, and our experience suggested that this anesthetic method might be useful for the patients with WPW syndrome and below-lower abdomen operation.