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1.
Korean Journal of Nephrology ; : 121-126, 2006.
Article in Korean | WPRIM | ID: wpr-66047

ABSTRACT

Goodpasture's syndrome (GS) is characterized by lung hemorrhage and glomerulonephritis and caused by autoimmune reaction between anti-glomerular basement membrane (GBM) autoantibodies and the alpha 3 (type IV) collagen chain. Some reports suggested that patients with anti-GBM autoantibody could be related with other autoimmune diseases including Graves' disease. We report a case of 14-year-old girl with Graves' disease treated with PTU for 4 years, who was admitted because of hemoptysis and dyspnea. Laboratory values included a serum creatinine value of 0.7 mg/dL, BUN 22 mg/dL, hemoglobin 3.9 g/mm3 and albumin 3.2 mg/dL. The thyroid function tests showed normal serum T3 and free T4, suppressed TSH, and elevated thyroglobulin Ab and TSH-R-Ab levels. Urinalysis showed 2+ for protein and many dysmorphic RBC/HPF. Both anti-GBM Ab and pANCA were positive serologically. In renal biopsy, the glomeruli showed mesangial proliferation and crescent formation with linear deposits of IgG along the GBM. This case is to represent the GS of patient with Graves' disease referring to medical documents.


Subject(s)
Adolescent , Female , Humans , Anti-Glomerular Basement Membrane Disease , Autoantibodies , Autoimmune Diseases , Basement Membrane , Biopsy , Collagen , Creatinine , Dyspnea , Glomerulonephritis , Graves Disease , Hemoptysis , Hemorrhage , Immunoglobulin G , Lung , Methylprednisolone , Thyroglobulin , Thyroid Function Tests , Urinalysis
2.
Korean Journal of Pediatric Hematology-Oncology ; : 330-334, 2005.
Article in Korean | WPRIM | ID: wpr-178949

ABSTRACT

Fusarium species are common soil saprophytes and plant pathogens. In humans, several species have been recognized as agents of superficial infections. Disseminated Fusariosis have been increasingly described in immunocompromised patients, especially in neutropenic patients. The prognosis is very poor despites antifungal therapy. This is the report of Fusarium oxysporum infection in a 6-year-old patient with relapsed acute leukemia and prolonged neutropenia. The patient presented with persistent fever and multiple erythematous papules with central necrosis or vesicle. Fuasrium oxysporum was isolated and cultured from a skin biopsy specimen. Initially, the patient failed to respond to conventional amphotericin B but recovered after treatment was switched to liposomal amphotericin B and voriconazole.


Subject(s)
Child , Humans , Amphotericin B , Biopsy , Drug Therapy , Fever , Fusariosis , Fusarium , Immunocompromised Host , Leukemia , Necrosis , Neutropenia , Plants , Prognosis , Skin , Soil
3.
Korean Journal of Dermatology ; : 1228-1231, 2003.
Article in Korean | WPRIM | ID: wpr-105103

ABSTRACT

Neonatal lupus erythematosus(NLE) is a rare disease characterized by the transplacental passage from the mother to the fetus of autoantibodies, particularly autoantibodies of Ro family. The patient with NLE exhibits one or more of the following findings: congenital heart block, cutaneous lupus lesions, hepatobiliary disease and hematologic disorders(thrombocytopenia, anemia). We report a case of NLE in a 2-week-old male infant, born of a clinically asymptomatic mother, presenting multiple, round, target-like lesions which have not been reported in the English and Korean literature. Both infant and mother were positive for anti-SSA/Ro and anti-SSB/La.


Subject(s)
Humans , Infant , Male , Autoantibodies , Fetus , Heart Block , Mothers , Rare Diseases , Skin
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