ABSTRACT
Motor and sensory nevre conduction velocities in the upper and lower limbs were evaluated in 30 patients of type I [insulin-dependent] diabetes mellitus and 15 age matched non-diabetic controls having no symptoms of peripheral neuropathy. Fasting blood glucose and glycosylated haemoglobin [HbA1C] levels were estimated to assess the glycaemic control in diabetic patients. Motor and sensory nerve conduction velocities were very highly significantly [P< 0.001] reduced in diabetic patients as compared to those in non-diabetic controls. A significant inverse correlation [P< 0.05] between duration of the disease and motor nerve conduction velocity of median nerve was demonstrated. There was also a significant inverse correlation [P< 0.05] between motor and sensory conduction velocities and fasting blood glucose level. This suggests a metabolic basis for the pathogenesis of diabetic neuropthy. Subclincal peripheral neuropathy was present in 36.67% of insulin-dependent diabetics
Subject(s)
Humans , Male , Female , Diabetic Neuropathies/etiology , Diabetic Neuropathies/diagnosis , Blood Glucose/analysis , Glycated Hemoglobin/bloodABSTRACT
Non-Insulin Dependant Diabetes Mellitus [NIDDM] is a major metabolic disorder. Insulin resistance is the primary abnormality predisposing to NIDDM. Genetic factors as well as environmental agents cause NIDDM in man. Hyperglycemia leads to development of complications. Present study was aimed to investigate NIDDM from a population perspective as a risk factor for development of complications. The study was conducted on 48 subjects. They were NIDDM patients and non-diabetic relative of type-II diabetics. Clinical symptoms, complications and blood glucose levels were recorded. Fifteen percent [15%] of NIDDM patients did not have a positive family history of diabetes. On diet control alone presented with more complications. There was statistically highly significant difference [p<0.01] in age of onset and total duration of diabetes between patients on oral hypoglycemics and on diet control. Body Mass Index [BMI] was higher in diabetics as compared to non-diabetics [p< 0.01]. Complete physical examination and routine glycosylated haemoglobin [HbA1C] should be carried out on regular basis to avoid development of complications
Subject(s)
Humans , Male , Female , Risk Factors , Blood Glucose/analysis , Glycated Hemoglobin/bloodABSTRACT
The definition of optimum growth in children in developing countries is still the most debated problem due to its complexity and diverse character of population with regards to region, socioeconomic status and heredity. The effectiveness of programmes aimed at improving nutrition can best be obtained by objective and periodic assessment of the nutritional status of representative communities. The study was conducted on 295 children aged 4-10 years belonging to low and middle socioeconomic status by a cross-sectional study design. The height, weight percentiles and Z scores were calculated and compared with National Centre for Health Statistics [NCHS] of American standards. The results showed that the mean weight and height [50th percentile] of children of both sexes lies below the 5th percentile of American standards. Weight for age and height for age showed more definite difference from American standard. We concluded that body size reflects the general housing standard and racial and socioeconomic influences on growth pattern must be taken into account in the interpretation of anthropometric data
Subject(s)
Humans , Male , Female , Child , Growth , Child DevelopmentABSTRACT
Glycosylated haemoglobin HbA[1c] and fasting blood glucose levels were estimated in 30 insulin dependent [type 1] and 30 non-insulin dependent [type 2] diabetics to find out correlation between these two glycaemic parameters. A positive correlation was found between HbA[1c] and fasting blood glucose levels. This correlation was, highly significant [P<0.01] in insulin dependent diabetics and very highly significant [P<0.001] in non insulin dependent diabetics