Protective activity of different concentration of tea polyphenols and its major compound EGCG against whole body irradiation-induced injury in mice / 中国中药杂志

<p><b>OBJECTIVE</b>To evaluate the different concentrate of tea polyphenols (TP) and its compound for irradiation-protection and investigate its mechanism.</p><p><b>METHOD</b>To evaluate the radioprotective activity, mice were exposed to whole body gamma irradiation. TP 80 and TP 50 (50, 10 mg x kg(-1)) and its major constituent epigallocatechin gallate (EGCG) (50, 10 mg x kg(-1)) were administered after irradiation to examine its inhibition against irradiation-induced injury.</p><p><b>RESULT</b>This study indicate that in comparison with non-irradiated controls, irradiation resulted in a significant reduction the spleen index (spleen weight/body weight 100), haematological parameters (RBC, WBC and PLT), activity of superoxide dismutase (SOD), and increase of malondialdehde (MDA) level in 28 days. Oral administration of TP (50 mg x kg(-1)) shown the best effect on reducing the irradiation-induced injury on mice studied, and showed a protective effect against irradiation-induced haematological parameters (RBC, WBC and PLT), the spleen index and MDA level significant reduction, and antioxidase activity (SOD) decrease.</p><p><b>CONCLUSION</b>The results suggest that TP 50 mg x kg(-1) and EGCG have in vivo antioxidant potential and radioprotective activity against whole body gamma irradiation in mice. It may be concluded that TP (50% EGCG) possess good irradiation-protective and antioxidant effect.</p>

Analysis of Hospital Preparation Utilization in Our Hospital / 中国药房

OBJECTIVE:To evaluate the role and function of hospital preparations.METHODS:A retrospective analysis was conducted on the utilization of hospital preparations in our hospital from July 1,2005 to June 30,2006.RESULTS:A total of 158 kinds of hospital preparations were used in our hospital,with their sales value totaling RMB 10.025 3 million,representing 1.13% of total drug sales.The top 10 selling hospital preparations accounted for 72.2% of all hospital preparations in sales value.A difference was seen in use of hospital preparations by outpatient and inpatient departments.CONCLUSIONS:Hospital preparations are indispensable for routine diagnosis and medication despite their small proportion in sales value of total drugs.

Economic Benifits of Hospital Pharmaceutical Services after Cancelling the Hospital Drug Price Addition / 中国药房

OBJECTIVE: To discuss the economic benefits of pharmaceutical care after hospital drug price addition has been cancelled. METHODS: To analyze the way to create economic benefits from hospital pharmaceutical services in China by drawing experiences from developed countries. RESULTS & CONCLUSIONS: Canceling of hospital drug price addition is conducive to the increase of the status of pharmacists. Medical institutions can profit from extending pharmaceutical services.

Composition and Influential Factors of Hospitalization Expenses in Inguinal Hernia Inpatients Under the Single-disease Payment Standard of Medical Insurance / 药物流行病学杂志

Objective:To analyze the hospitalization expenses in inguinal hernia inpatients under the single-disease payment standard of medical insurance.Method:A retrospective study was performed to analyze the data of inguinal hernia patients who received inguinal herniorrhaphy in 2006.According to the regulations worked out by the Beijing Medical Insurance Affairs Administration,32 cases were selected and their medical costs were characterized.Result:The average hospitalization expense in inguinal hernia patients was 5722.37?2967.66 yuan,including surgery cost(45.6%) and drug cost(26.7%).The surgery cost level depended on the selection of various hernia prosthetic mesh and the drug cost depended on the selection of various anti-infective drugs.The hospitaliztion expenditures were lower in 18 cases than the payment permission in the medical insurance standard but higher in the other 14 cases.The sex composition,surgery cost, drug cost and laboratory cost showed a significant difference between the two groups(P

Pharmacoeconomic Evaluation of Individual Antimicrobial Therapeutic Schemes in Appendectomy Patients / 中华医院感染学杂志

OBJECTIVE To analyze the antimicrobial therapeutic schemes in appendectomy inpatients so as to(evaluate) the economic impact factors of each project.METHODS Totally 286 medical cases of appendectomy inpatients were chosen and analyzed from 2003 to 2005.The antimicrobial agent costs of each scheme were evaluated by(using) cost minimization analysis of pharmacoeconomic method.RESULTS There were 24 kinds of antimicrobial therapeutic schemes used by 286 cases.The commonest schemes were nitrodazoles + ?-lactams and nitrodazoles + ?-lactams + aminoglycosides(or clindamycin). The drug costs were 1671.46 and 1977.13 yuan(RMB)(individually) in combination of two or three kinds of antimicrobial agents.Choosing metronidazole instead of ornidazole could reduce drug fee significantly,which was also observed in choosing ceftazidime instead of other ?-lactams.CONCLUSIONS The antimicrobial drug utilization in our hospital is rational as a whole.Considering of economic factors,using metronidazole and ceftazidime(administering clindamycin if necessary) may be better than other schemes for prventing wound infection.

Utilization of Traditional Chinese Medicine Injections in Our Hospital During 2001～2006 / 中国药房

OBJECTIVE:To analyze the drug utilization of traditional Chinese medicine injections in our hospital so as to provide scientific basis for clinical rational use of traditional Chinese medicine injections.METHODS:The data of annual consumption and total consumption of traditional Chinese medicine injections in our hospital during 2001～2006 were calculated,and the DDDs and the daily average costs of traditional Chinese medicine injections were analyzed statistically.RESULTS: The annual consumption of traditional Chinese medicine injections showed an increasing trend in our hospital during 2001～2006,with the consumption sum of the top 10 traditional Chinese medicine injections showing a higher proportion,which had a great impact on the total consumption of traditional Chinese medicine injections.Moreover,the rank ratios were less than one for both consumption sum and DDDs of those drugs with high average daily costs.CONCLUSION: Great importance should be attached to the DDDs of traditional Chinese medicine injections and the post-marketing reevaluation for traditional Chinese medicine injections should be intensified.