ABSTRACT
[Objective] To study the protective effect of Xing Nao Jing (XNJ) on cultured cortical neurons in rats. [Methods] Primary cultured cortical neurons were applied to observe the effect of XNJ in counteracting the excitotoxicity ofglutamic acid. [Results] XNJ decreased the release of intracellular lactic dehydrogenase induced by glutamic acid and reduced the histological changes of cultured cortical neurons. [Conclusion] XNJ can counteract the excitotoxicity of glutamic acid and protect cultured cortical neurons in rats.
ABSTRACT
OBJECTIVE:To study the protective effects of Xingnaojing(XNJ)and Ligustrazine(Lig)on rat's cortical neu_ rons of primary culture.METHODS:The effects of XNJ and Lig in counteracting the excitotoxicity of glutamic acid(10?l/L,3h)in rat's cortical neurons of primary culture were observed.RESULTS:Both XNJ and Lig could decrease the release of LDH from cells into culture medium and reduce the changes in cell morphology.CONCLUSION:XNJ or Lig can protect cultured cortical neurons from excitotoxicity of glutamic acid and more obvious effect can be initiated through combined use of them.