ABSTRACT
A 13 year adolescent boy presented with complaints of progressive loss of speech and seizure disorder for the past 1 year. The boy was developmently normal before the onset of illness. There was history of subtle trauma to head. He started communicating with signs followed by paucity of speech progressed to complete aphasia and abnormal behavior in the form of burst of aggressiveness and hyperactivity. Boy had partial, generalized tonic-clonic seizures occurred during sleep. Mental status examination revealed abnormal behaviour, attention deficits, auditory agnosia and aphasia (both expressive and receptive). All relevant investigations including BERA were normal.EEG showed repetitive spikes and wave activity in bilateral parietooccipital regions during nonrapid eye movement. Clinical features and EEG led to a diagnosis of Landau Kleffner Syndrome . He was started on Lamotrigine, steroid and speech therapy. The boy started showing improvement of symptoms in form of understanding of short sentences.
ABSTRACT
Crude 50% ethanolic extract of P. hysterophorus flowers exhibited trypanocidal activity in vitro at all the four concentrations tested i.e. 5, 50, 500 and 1000 micrograms/ml. In vivo trial revealed that the extract exerted antitrypanosomal effect at doses of 100 and 300 mg/kg body wt, i.p. as evidenced by significantly reduced (P < 0.01) mean parasitaemia on days 3, 4, 5 and 6 when compared with untreated control group. Further at 100 and 300 mg/kg, body wt doses, the survival period was significantly (P < 0.05) prolonged as compared to control group. The extract was, however, found toxic to the animals at 1000 mg/kg dose.
Subject(s)
Animals , Female , Male , Mice , Plant Extracts/pharmacology , Trypanocidal Agents/pharmacology , Trypanosoma/drug effects , Trypanosomiasis/drug therapyABSTRACT
Fifty two patients of severe hypertension, diastolic blood pressure > or = 115 mmHg, with or without acute complications, were treated with sublingual nifedipine 10 mg or sublingual captopril 25 mg in a randomized prospective in patient study with careful clinical monitoring. Both the drugs were safe and effective in rapidly lowering blood pressure. Nifedipine appeared to be superior to captopril with earlier onset of action, greater magnitude of response and longer duration of action. No significant side effects were observed in either of the two groups.
Subject(s)
Administration, Sublingual , Adolescent , Adult , Aged , Blood Pressure , Captopril/administration & dosage , Diastole , Emergencies , Female , Humans , Hypertension/drug therapy , Male , Middle Aged , Nifedipine/administration & dosage , Prospective StudiesABSTRACT
JC:------------ABSTRACT------------------------- P4 Osteoclastoma seen between 1965 and 1984 is presented. All patients received megavoltage therapy using Telecobalt. Tumour dose of 45 Gy to 55.3 Gy in 15 to 18 fractions had been delivered. All patients had quantitation of pre-treatment tumour volume and post-treatment response using a radiographic grid. CT scan measurements have complimented the grid quantitation in recent years. Follow through visits from 5 to 24 years post-treatment (mean follow up 9.2 years) have shown optimum tumor regression, bone recalcification and restitution of joint functions amongst these patients. No case of bone sarcoma has been detected. Our observations lead us to support megavoltage radiation therapy as the treatment of choice for accessible and inaccessible osteoclastoma.
Subject(s)
Adolescent , Adult , Bone Neoplasms/radiotherapy , Female , Giant Cell Tumors/radiotherapy , Humans , MaleABSTRACT
The study evaluated 121 consecutive unoperated cases of retinoblastoma in children. They received radiation as the primary treatment for their ocular disease. The stage grouping was done according to Reese classification. Ninety four children had their disease evaluated by CT scan. All except one had imaged lesions in both eyes. In addition, twenty six had thickened optic nerves and twenty one showed chiasmal infiltration. Radiation field selection was based on clinical and CT imaged disease. A tumor dose of 4500c Gy in 16 to 19 fractions over 18 to 24 days was delivered by cobalt teletherapy. The target volume encompassed ora serrata anteriorly and optic chiasma posteriorly in all cases. Tumor response and patient survival was correlated with the initial stage and radiation factors utilised amongst them. Encouraging results were obtained using three field radiation technique with an open anterior field and a TDF between 75 and 90.