Elevation and depletion induced by cholesterol derivatives in the level of total lipids on the major brain parts of albino rat

Changes in the level of total lipids on albino rat's brain [cerebrum, cerebellum and brain stem] were evaluated following the administration of four Cholesterol derivatives 3 beta-Acetoxy-5-bromo-6 beta hydroxy-5 alpha-Cholestane A [I], 3 beta-Acetoxy-6-dimethyl amino-Cholest-5-ene B [II], 3 beta Chloro-5-bromo-6 beta-nitro-5 alpha-Cholestane C [III] and 6 beta-Aminopyrimidino-Cholest-4en-3-one D [IV]. Experiments were carried out on four groups of six male albino rats weighing 200 +/- 20 gm. Control albino rats were administered saline solution intraperitoneally [ip.], while the other experimental groups were given 0.3 mg/kg body weight of steroidal solutions which was prepared in peanut oil

Estimation of gangliosides by cholesterol derivatives on cerebrum, cerebellum and brain stem of albino rats

Changes in the level of gangliosides on the albino rats' brain [cerebrum, cerebellum and brain stem] were evaluated, following the administration of four steroidal compounds as 3 beta-Acetoxy-5-bromo-6 beta hydroxy-5 alpha-cholestane [A] [I], 3 beta-Acetoxy-6-dimethylamino cholest-5-ene [B] [II], 3 beta-chloro-5-bromo'6 beta-nitro5 alpha-cholestane [C] [III] and 6 beta-Aminopyrimidino-cholest-4en-3-one [D] [IV]. Experiments were carried out on four groups of six male albino rats weighing 200+20 gm. Control albino rats were administered saline solution intraperitoneally [ip,], while other experimental groups were given 0.3 mg/kg body weight of steroidal solution which was prepared in peanut oil

Neurotoxicological effects of steroidal compounds in changes of cholesterol level on albino rat brain

Changes in the level of cholesterol in albino rat brain [cerebrum hemisphere, cerebellum and brain stem] were evaluated following the administration of four steroidal derivatives as 3 beta-Acetoxy-5-bromo 6-beta succinimido, 5 alpha-cholestane A[I], 3 beta-chloro-5-bromo 6 beta-amino-5 alpha-cholestane B[II], 3 beta-Acetoxy-6-phthalimid choloest-5-ene C[III] and 6-nitro cholest 5-eno [3 alpha-4 alpha-d] oxazolidin-2-one D[IV]. Experiments were carried out on four groups of six male albino rats weighing 200 +/- 20gm. Control rats were administered normal saline water intraperitoneally [ip] while the other experimental groups were given 0.3 mg/kg bodyweight of steroidal solution which was prepared in peanut oil