ABSTRACT
Objective: To establish the rational drug use standard for elderly hypertensive patients after comprehensive assessment, so as to provide evidence for rational drug use in clinics. Methods: Such standards as Beers, STOPP and START were summarized, key items were extracted,duplicate contents were deleted,and the initial standard was formed and used as the first round questionnaire. The Delphi method was used to conduct the second round expert consultation questionnaire,and the positive coefficients, authority and coordination degree of the experts were evaluated. Results: A total of 10 experts participated in the consultation, and the effective re-covery rate of the second round was 100% and the average authority coefficient was 0. 88. The coordination coefficient of the two rounds was 0. 57 and 0. 76, respectively. The standard of rational drug use for the elderly patients with hypertension after comprehensive as-sessment was finally completed. The standard contained 13 comprehensive assessment contents and 21 drug warning entries. Conclu-sion: After 2 rounds of expert consultation,the opinions tend to be uniform with high degree of coordination. The standard can provide reference for clinicians and clinical pharmacists to use drugs rationally. At the same time,it also provides ideas for the establishment of rational drug use standards for other diseases.
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OBJECTIVE:To provide reference for rational use of recombinant human granulocyte-colony stimulating factor (rhG-CSF) in cancer patients. METHODS:Referring to the expert advice and guideline of clinical application of rhG-CSF at home and abroad,DUE criteria on rhG-CSF for cancer patients was established;questionnaire was designed,and the medical re-cords of rhG-CSF in a third grade class A hospital was evaluated. RESULTS:The DUE criterion on rhG-CSF for cancer patients included 3 parts,such as drug indications,the course of medication and medication results,14 items in total. Through the imple-mentation of DUE,retrospective evaluation of 220 medical records showed that the application of rhG-CSF was up to the stan-dard in respects of drug indications,no contraindication,routine blood test and drug interaction monitoring at least twice every week,there still was irrational phenomenon. CONCLUSIONS:The established DUE criterion on rhG-CSF for cancer patients is with the characteristics of definite content,target and paracticabilitg,which can provide reference for the work development of clinical pharmacists.
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OBJECTIVE:To evaluate the bioequiavailability of two kinds of loratadine tabletes in Chinese healthy volunteers.METHODS:A single oral dose 40 mg of two loratadine preparations(reference and test preparations)was given to 20 volunteers(whom were divided into two groups)in a randomized cross-over study.The concentration of loratadine in plasma was determined by solid phase extraction-HPLC.RESULTS:The main pharmacokinetic parameters of reference and test preparations were as follows:Cmax were(17.00?3.90)and(18.41?2.58)?g?L-1;tmax were(1.06?0.25)and(0.93?0.20)h;t1/2Ke were(1.34?0.38)and(1.08?0.38)h;AUC0～∞ were(37.41?17.38)and(36.38?16.73)?g?h?L-1;AUC0～8 were(35.11?15.72)and(34.76?15.34)?g?h?L-1,respectively.The relative bioavailability of the test preparation was(99.0?18.7)% as against the reference preparation,and no significant differences was noted for the two formulations in ANOVA and two-one side t test.CONCLUSION:The two formulations were bioequivalent.