ABSTRACT
Objective Benign childhood epilepsy with centrotemporal spikes (BECT) is the most common partial epilepsy syndrome in children, and responds well to carbamazepine (CBZ), oxcarbazepine (OXC), and valproic acid (VPA). The aim of this study is to investigate the therapeutic effect of OXC on BECT. Methods We retrospectively discussed a case of partial epilepsy in a 6-year-old boy with no abnormality on neuroradiologic examination. Results The patient′s seizures were easily controlled by administration of OXC, but electroencephalography (EEG) identified deterioration of the EEG features following the introduction of OXC monotherapy. Then OXC was gradually decreased in dose and substituted with VPA. When VPA was increased to the dose of 0.5g/d, the boy had no more seizures and exhibited normal EEG in the conscious state. Conclusion OXC may induce new types of seizure and aggravate EEG features although it is considered to be the first-line anti-epileptic drug (AED) and much better tolerated than either phenytoin or CBZ.
ABSTRACT
Objective:To investigate neuroprotection of calcitriol in LPS-induced rat systemic inflammation and underlying mechanism. Methods:Adult male Sprague-Dawley rats were randomized into three groups: blank group(6 rats),calcitriol group [23 rats,4?g/(kg?d)?14d] and control group [23 rats,fat milk,4ml/(kg?d)?14d].46 rats were induced systemic inflammation by intraperitoneal injection of LPS(10mg/kg) on day 14th,1 hour after the administration.On post-injection 3,6,9 hour,36 rats were anesthetized to death and obtained rat brain tissue to detect activity of NF-?B by EMSA and to assess TNF-?,IL-10 concentration by ELISA.HE staining was used to determine brain injury. Results:LPS effectively activated NF-?B,enhanced TNF-? expression,induced sporadic neurons damage in brain in the control group and in time-dependent,compared with blank group rats.Calcitriol significantly down-regulated NF-?B activity,TNF-? expression but enhanced IL-10 expression at all time point evaluated,compared with the control group rats. Conclusion:Intraperitoneal injection of LPS can induce brain damage,Calcitriol modulate the inflammatory-antiinflammatory cytokine balance by downregulating activation of NF-?B,reducing over express of TNF-? and elevating IL-10 concentration.
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Objective: To investigate the clinical and familial characteristics of essential tremor(ET).Methods: The clinical features and familial history of 2 ET patients were reviewed.Results: The clinical manifestation of the probands was intentional tremor,which could be ameliorated by alcohol.The incidence of the disease was 55.6% and 43.7% among the first-and second-degree relatives of the two families.Propranolol,a ?-adrenoceptor antagonist,was an effective drug for ET.Conclusion: Clinically ET is characterized by postural or intentional tremor,which mostly involves the hands and head.Positive result of the alcohol test is shown in most ET patients.It is commonly assumed to be a genetic disease.
ABSTRACT
Objective To study the efficacy and safety of domestic-made Lomerizine hydrochloride for treating migraine.Methods 53 patients with migraine were randomly divided into Lomerizine hydrochloride group(27 cases) and control group(26 cases),and treated with Lomerizine hydrochloride or placebo orally respectively.The total follow-ups were 12 weeks.Headache frequency was served as main evaluation index,and duration and degree of headache,simultaneous complications and headache scores as secondary evaluation indexes.Results(1) The 4,8 and 12 weeks after treatment,the scores of headache frequency,lasting time of headache,degree of headache,accompany symptom and total scores in Lomerizine hydrochloride group were decreased significantly compared with control group(all(P