Clinical features and risk factors of 90 patients with diabetic foot recurrent infection / 中国基层医药

Objective To investigate the clinical features and risk factors of diabetic foot recurrence infection in diabetes mellitus (DM) patients.Methods A total of 158 patients with diabetic foot infection from January 2014 to December 2017 admitted to the First Affiliated Hospital of Xiamen University were selected in the study.There were 90 patients with diabetic foot recurrence.The clinical data of patients with recurrent infection and non-recurrent infection were compared and analyzed.Multivariate logistic regression was used to analyze the risk factors associated with recurrent infection of diabetic foot.Results Ninety patients with recurrent infection of diabetic foot were cultured with 108 strains of pathogens,of which Gram-positive (G +),Gram-negative (G-),and other pathogens accounted for 54.63 ％ (59 strains),39.81％ (43 strains),5.56％ (6 strains),respectively.The differences in disease duration,age,white blood cell count,hs-CRP,hemoglobin,fibrinogen,albumin levels,and Wanger grade 4 to 5 ratio,peripheral vascular lesions of the lower extremities,recent use of antibiotics and the healing time of ulcers in patients of diabetic foot recurrence and non-recurrent infections were statistically significant (t =6.003,6.132,3.144,4.322,4.513,11.179,7.164,x2 =4.269,8.613,25.083,23.298,all P ＜ 0.05).Multivariate analysis showed that the independent risk factors for diabetic foot recurrence were peripheral vascular lesions of the lower extremities,recent use of antimicrobial agents,ulcer healing time more than 65 days (x2 =5.134,4.807,10.512,all P ＜ 0.05).Conclusion The results show that patients with ulcer healing time more than 65 days,vascular lesions around the lower extremities,and diabetic foot who recently used antibiotics have a higher risk of recurrent infections.Close observation should be made to take early precautionary measures based on the patients'own condition.

Clinical features and risk factors of 90 patients with diabetic foot recurrent infection / 中国基层医药

Objective@#To investigate the clinical features and risk factors of diabetic foot recurrence infection in diabetes mellitus (DM) patients.@*Methods@#A total of 158 patients with diabetic foot infection from January 2014 to December 2017 admitted to the First Affiliated Hospital of Xiamen University were selected in the study.There were 90 patients with diabetic foot recurrence.The clinical data of patients with recurrent infection and non-recurrent infection were compared and analyzed.Multivariate logistic regression was used to analyze the risk factors associated with recurrent infection of diabetic foot.@*Results@#Ninety patients with recurrent infection of diabetic foot were cultured with 108 strains of pathogens, of which Gram-positive(G+ ), Gram-negative(G-), and other pathogens accounted for 54.63%(59 strains), 39.81%(43 strains), 5.56%(6 strains), respectively.The differences in disease duration, age, white blood cell count, hs-CRP, hemoglobin, fibrinogen, albumin levels, and Wanger grade 4 to 5 ratio, peripheral vascular lesions of the lower extremities, recent use of antibiotics and the healing time of ulcers in patients of diabetic foot recurrence and non-recurrent infections were statistically significant(t=6.003, 6.132, 3.144, 4.322, 4.513, 11.179, 7.164, χ2=4.269, 8.613, 25.083, 23.298, all P<0.05). Multivariate analysis showed that the independent risk factors for diabetic foot recurrence were peripheral vascular lesions of the lower extremities, recent use of antimicrobial agents, ulcer healing time more than 65 days(χ2=5.134, 4.807, 10.512, all P<0.05).@*Conclusion@#The results show that patients with ulcer healing time more than 65 days, vascular lesions around the lower extremities, and diabetic foot who recently used antibiotics have a higher risk of recurrent infections.Close observation should be made to take early precautionary measures based on the patients' own condition.

Salivary gland dynamic imaging for salivary gland damage in Sjogren's syndrome patients with normal Young's modulus value / 中华核医学与分子影像杂志

Objective To evaluate the damage of the salivary gland in Sjogren's syndrome (SS)patients with normal Young's modulus value (YMV) using salivary gland dynamic imaging (SGDI).Methods A total of 78 parotid glands and submandibular glands of SS patients and 100 parotid glands and submandibular glands of healthy people were collected in this retrospective study.The difference of YMV between 2 groups was analyzed with two-sample t test;receiver operating characteristic (ROC) curves of YMV were drawn to calculate the area under carve (AUC) and cut-off values.SGDI was used to observe the uptake ratio of 15 min (UR15) value in the SS salivary glands with normal YMV.Results The YMV of left parotid/submandibular glands and right parotid/submandibular glands were not statistically different in both SS patients and healthy people (t values:from-1.192 to-0.404,all P＞0.05).The YMV of parotid/submandibular glands in SS patients was higher than that in healthy people:(15.39±8.08) vs (9.33±2.21) kPa,(14.35±5.33) vs (9.18±2.36) kPa (t values:7.169 and 8.662,both P＜0.05).ROC curves showed that the AUC of parotid glands and submandibular glands were 0.78 and 0.83.As the cut-off values of YMV were 10.85 kPa and 10.95 kPa,the sensitivity were 69.23％ (54/78) and 73.08％ (57/78),the specificity were 77.00％ (77/100) and 83.00％ (83/100),the positive predictive value were 70.13％ (54/77) and 77.03％ (57/74),the negative predictive value were 76.24％ (77/101) and 79.81％ (83/104),respectively.There was no statistically difference between YMV and UR15 for evaluating the SS parotid glands and submandibular glands (x2 values:0.963 and 0.896,both P＞0.05).The UR15 value of 78 SS parotid glands and submandibular glands were 1.42±0.97 and 1.19±0.83,respectively.About 58.33％ (14/24) parotid glands with normal YMV (＜10.85 kPa) and 76.19％ (16/21) submandibular glands with normal YMV (＜10.95 kPa)had reduced cellular uptake in SS patients.Conclusions Parotid glands and submandibular glands in SS patients are damaged,and the tissue hardness is increased.SGDI can discover the cellular damage in SS salivary glands with normal YMV.

Dynamic changes of reproductive hormone levels and related factors in old and middleaged men in health examination / 中华男科学杂志

Objective@#To investigate the dynamic changes of serum reproductive hormone levels in old and middleaged males in health examination and their correlation with age and lipid profile.@*METHODS@#This study included 4 333 men in health examination from January 2011 to December 2014. The men were aged from 40 to 85 years old and divided into seven fiveyearspan age groups. We determined the levels of serum testosterone (T), luteinizing hormone (LH), folliclestimulating hormone (FSH), estradiol (E2), progesterone (P), prolactin (PRL), total cholesterol (TC), triglyceride (TG), lowdensity lipoprotein cholesterol (LDLC), highdensity lipoprotein cholesterol (HDLC), and the testosterone secretion index (TSI = T/LH). We analyzed the obtained data using SPSS Pram, KruskalWallis H test, MannWhitney U test, exponential regression, and Spearman correlation analysis.@*RESULTS@#Statistically significant differences were found in LH, FSH, E2 and TSI among the seven age groups (P40 years old males. T and TSI were reduced in the 40－59 years old men from 2011 to 2014, and so was E2 in the 40－54 yr group. Lowlevel testosterone is closely related to dyslipidemia.

Clinical Characteristics and Imaging Diagnosis of the Traumatic Carotid Cavernous Fistula(TCCF) with Hemorrhage / 实用放射学杂志

Objective To explore the clinical and imaging characteristics of traumatic carotid cavernous fistula(TCCF) with hemorrhage.Methods There were thirteen cases of TCCF underwent car accidents combined with epistaxis or intracranial hemorrhage between 1990 and 2000.Their clinical symptoms,CT,MR,and digital substract angiogram(DSA) were retrospectively analysed.Results There were special clinical and imaging characteristics in TCCF.Small amount of epistaxis and isolateral loss of sight might be found in cases with epistaxis at early stage,but delayed fatal and massive epistaxis occured at various time after trauma.Cranial base fracture and pseudoaneurysm were special imaging signs.In the TCCF cases with intracranial hemorrhage,prominent and tortuose cortical drainage veins might be found.And pseudoaneurysm at posterio-lateral wall of cavernous sinus might be another special imaging sign.Conclusion Small amount of epistaxis at early stage,cranial base fracture,pseudoaneurysm,prominence and tortuosity of cortical veins are characteristic diagnostic references for TCCF with hemorrhage.Emergent DSA examination at early stage should be regarded as a key step for diagnosis and treatment.