Economic burden of disease studies in patients with epilepsy / 中华预防医学杂志

<p><b>OBJECTIVE</b>To analyze the various factors affecting the economic burden of disease in patients with epilepsy.</p><p><b>METHODS</b>This research used a multi-stage random sampling method, comprehensive intervention and without intervention of the epilepsy project group conducted a field survey of health examination among patients with epilepsy of 874 (422 cases in intervention group and 452 cases in control group) in Mengzhou, Xiuwu, Yancheng, Yuanhui, Wuyang, Linying, Shaoling, Xinye and Fangcheng. DALY indicators combined with human capital approach was used to measure the economic burden of disease in patients from two aspects of the direct economic burden and indirect economic burden.</p><p><b>RESULTS</b>The age of comprehensive intervention group was (43.7 ± 8.5) years old, and it was (44.4 ± 7.2) years old in no intervention control group. The age difference was not statistically significant (P = 0.365). The direct economic burden per capita of the survey was 1019.6 yuan per year, while epilepsy drugs 434.2 yuan per year, 485.2 and 66.4 yuan per year in the intervention group, while 1518.5 and 777.5 yuan per year in the control group. Each object in this study lost (16.67 ± 10.01) DALY, with 8.58 DALY in intervention group and 24.23 DALY in no intervention control group. The per capita indirect economic burden of the intervention and control groups were 68 115.2, 401 036.5 yuan, the per capita total economic burden of disease were 68 600.5, 408 755.0 yuan. Multivariate logistic regression analysis showed that disease duration year of ≥ 37, 30 - 36, 20 - 29, 10 - 19, OR (95%CI) were 4.44 (2.37 - 8.33), 3.32 (1.85 - 5.94), 3.25 (1.90 - 5.56), 2.53 (1.46 - 4.41). If patients with longer duration, the more serious the patient's disease burden. Medication compliance (in order to comply with a good group control) OR (95%CI) was 3.37 (2.34 - 4.83), medication in the single form (serving multi-drug groups for control) OR (95%CI) 0.41 (0.29 - 0.59). Serving a single agent and good compliance of economic burden of disease were lighter.</p><p><b>CONCLUSION</b>Epilepsy caused serious economic damage. Longer duration, medication adherence poor and serving more than medicine by heavier economic burden of disease; comprehensive intervention could reduce the economic burden of disease of patients with epilepsy.</p>

Cost-utility analysis of comprehensive intervention on epilepsy / 中华流行病学杂志

Objective To discuss the cost-utility regarding the effect of comprehensive intervention program on epilepsy.Methods 874 cases with epilepsy were investigated in 9 pilot sites in Hcnan province.Cost of epilepsy comprehensive intervention was calculated based on the research projects of epilepsy prevention and management of rural areas.Disability-adjusted life year (DALY)and quality adjusted life year (QALY) were used as utility index for cost-utility analysis.Results Of the 874 cases,8.58 DALY was lost and 27.95 QALY was obtained per capita in the intervention group (422 cases).The costs per QALY and DALY obtained were 2454.10 and 7995.40 Yuan,respectively.Relative to the non-intervention control group (452 cases),the costs for QALY obtained by the intervention group had reduced.The investment would reduce 21 735.10 Yuan when each additional DALY was saved.Conclusion Epilepsy caused serious economic burden to the society,families and the patients themselves.Comprehensive intervention program could reduce the economic burden of the disease thus yielding high cost-benefit.This program was deserved to be promoted.