Determination of R(-)- isomer in repaglinide tablets by capillary electrophoresis / 浙江大学学报·医学版

<p><b>OBJECTIVE</b>To develop a capillary electrophoresis system for enantiomeric impurity test of repaglinide.</p><p><b>METHODS</b>An uncoated fused silica capillary (50 μm×50 cm, with an effective length of 41 cm) was used. The running buffer was composed of 30 mmol/L NaH2PO4 and 5 mg/ml carboxymethyl-β-cyclodextrin(pH 3.5).</p><p><b>RESULTS</b>Linear range was 2.00-80.00 μg/ml (correlation coefficient was 0.9993). The average recovery rate was 92.5% to 105.0%.</p><p><b>CONCLUSION</b>The method is simple, accurate and sensitive and it can be used for determination of enantiomeric impurities in repaglinide tablet.</p>

Determination of enantiomeric impurity in levocetirizine tablets by capillary electrophoresis / 浙江大学学报·医学版

<p><b>OBJECTIVE</b>To determine enantiomeric impurity in levocetirizine tablets by using capillary electrophoresis.</p><p><b>METHODS</b>The effects of pH and the concentrations of sulfated-Β-cyclodextrin (S-Β-CD) and buffer salt on chiral resolution were examined with S-Β-CD as chiral selector.</p><p><b>RESULTS</b>A good enantioseparation of cetirizine was achieved with 30 mmol/L NaH2PO4 buffer solution (pH 7.0) containing 20 g/L of S-Β-CD.</p><p><b>CONCLUSION</b>The method developed in the study is sensitive and reliable for determination of enantiomeric impurity in levocetirizine tablets.</p>