ABSTRACT
Introduction: Dry eye disease (DED), as defined by thedry eye work shop (DEWS II) guidelines, is a multifactorialdisease with various etiologies ranging from instability andhyperosmolarity of the tear film, inflammation and damageof the ocular surface and neurosensory abnormalities. Studywas done with the purpose to report the prevalence of dry eyedisease (DED) in western India.Material and Methods: This was a cross sectional studyconducted from April 2018 to March 2019. Patients fromoutpatient department > 18 years of age were selected basedon systematic random sampling. The ocular surface diseaseindex (OSDI) questionnaire was explained to the patientsand asked to fill-up and the total OSDI score was calculated.Based on the OSDI scoring, DED prevalence was calculated.Demographic details of the patients were noted and comparedbetween all patients and those with DED.Results: Of the 578 patients included in the study, 198patients (34.26%) had DED. Of those, 95 (47.98%) patientshad mild DED, 63 (31.82%) had moderate DED and 40(20.20%) had severe DED. The mean age of patients withDED was 50.63±18.69 years. Females (54.04%) were morecommonly affected compared to males (45.96%). There wassignificant difference in mean age among the total patientsand DED patients (P= 0.03). The gender ratio was notsignificantly different among total patients and DED patients(P=0.17).Conclusion: The hospital-based prevalence of DED inwestern India is 34.26%. The disease is more common inelderly females.
ABSTRACT
Introduction: Cataract is the most common surgicalprocedure. Study was done to compare the effect of nepafenac0.1% plus prednisolone 1% vs prednisolone 1% alone incontrolling ocular inflammation after phacoemulsificationMaterial and Methods: A total of 140 patients wererandomized to receive prednisolone 1% (group I) vsnepafenac plus prednisolone 1% (group II) after uneventfulphacoemulsification. Patients were examined on first day,one week and one month for vision, slit lamp evaluation foranterior segment inflammation and cystoid macular edema.Results: Average visual acuity was 6/9 in both groups.Anterior segment inflammation was significantly less in groupII on first post operative day. On later visits, there was nosignificant difference in inflammation in both groups. CMEwas not seen in any group.Conclusion: This study suggests that addition of nepafenac0.1% to prednisolone 1% significantly reduces the intraocularinflammation after phacoemulsification in the earlypostoperative period.
ABSTRACT
Purpose: To evaluate safety and efficacy of intravenous pulse cyclophosphamide (CyP) in acute macular serpiginous choroiditis (SC). Methods: Patients with acute macular SC with lesions threatening and/ or involving fovea were enrolled. All patients received CyP (1 g/m2) for 3 days followed by high‑dose oral steroids (1.5 mg/kg) tapered over 6 months and monitored for visual acuity, response to treatment and systemic side effects. Results: Eight patients (seven unilateral and one bilateral) with median age of 27 years (range: 13-40 years) were recruited. Mean visual acuity at presentation was 0.71 ± 0.35 logarithm of the minimum angle of resolution while postpulse visual acuity was 0.40 ± 0.32. Final mean visual acuity at 1‑year was 0.31 ± 0.23 (P ≤ 0.05). Three eyes had recurrence and 3 patients developed transient hair loss with no other adverse effect. Conclusion: Intravenous CyP provides rapid resolution of lesion activity and thereby helps in maintaining good functional acuity.