ABSTRACT
Objective To investigate the pharmacodynamic action of Yunkang Capsule(YKC).Methods The animals were divided into YKC groups(at high-,moderate-and low-dosage respectively),diphenidol control group,model control group and blank control group.The action of YKC on vertigo and thrombosis,hemorrheologic indexes,piamatral microcirculation and free radicals of the animal models were observed.Results YKC could significantly prolong the latency of vertigo,reduce wet weight of thrombus,decrease blood viscosity,plasma viscosity and hematocrit,promote the dilation of piamatral micro-vessels,increase the amount of interweave microdot,increase plasma SOD activity and decline plasma MDA content of animal models.Conclusion YKC has actions of counteracting vertigo and thrombosis,improving hemorrheology and microcirculation,and clearing away free radicals.
ABSTRACT
In step-down tests in mice,the effects of L -proline 0.1 - 100?g ? mouse-1 icv on memory acquisition were not observed, but L -proline0. l~10?g ? mouse-1 icv could significantly improve the anisodine- induced impairments of memory acquisition. This effect of L-proline 1?g ? mouse-1 icv could not be antagonized with D-2-amino-5-phosphonovaleric acid(APS), the N-methyl-D-aspartate (NMDA) receptor antagonist. L-proline 1?g ? mouse-1 icv could also improve memory acquisition impairment induced by high GABA level in brain. This results suggested that L - proline may improve the memory as the modulator or possibly through GABA.