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Objective@#To evaluate the effectiveness and safety of nab-paclitaxel plus platinum as first-line chemotherapy for ovarian cancer (OC). @*Methods@#Patients administered platinum combined with nab-paclitaxel as first-line chemotherapy for epithelial OC, fallopian tube cancer, or primary peritoneal cancer from July 2018 to December 2021 were retrospectively evaluated. The primary outcome was progression-free survival (PFS). Adverse events (AEs) were examined. Subgroup analysis was performed. @*Results@#Seventy-two patients (median age, 54.5 years; range, 20.0–79.0 years) were evaluated, including 12 and 60 administered neoadjuvant therapy and primary surgery with subsequent chemotherapy, respectively. The median follow-up duration was 25.6 months, and the median PFS was 26.7 (95% confidence interval [CI]=24.0–29.3) months in the whole patient population. In the neoadjuvant subgroup, the median PFS was 26.7 (95% CI=22.9–30.5) months vs. 30.1 (95% CI=23.1–37.1) months in the primary surgery subgroup. Twenty-seven patients were administered nab-paclitaxel plus carboplatin and had a median PFS of 30.3 (95% CI=not available [NA]–NA) months. The commonest grade 3–4 AEs included anemia (15.3%), white blood cell decreased (11.1%), and neutrophil count decreased (20.8%). No drug-related hypersensitivity reactions occurred. @*Conclusion@#Nab-paclitaxel plus platinum as first-line treatment in OC was associated with a favorable prognosis and was tolerable in patients with OC.
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Objective To analyze the relationship between the level of serum homocysteine and cerebral artery stenosis in cerebral infarction patients.Methods Clinical data from 165 cerebral infarction patients who had been done cerebral angiography examination were analyzed.According to the level of serum homocysteine,the patients were divided into 5.0-15.0 μmol/L group,15.1-20.0 μmol/L group and above 20.1 μmol/L group.Other risk fac-tors including age,gender,blood pressure,blood lipid and blood glucose were recorded.The number of cerebral vascu-lar stenosis in different parts of brain were analyzed,and then make a decision of the relationship between the level of serum homocysteine and cerebral artery stenosis,as well as the other risk factors.Results Among 165 cases,74 cases (48.15%)came from 5.0-15.0 μmol/L group and the number of stenosal cerebral vascular was 36strips,50 cases (30.12%)came from 15.0-20.0 μmol/L group and the number of stenosal cerebral vascular was 66 strips,41 cases (24.70%)came from above 20.1 μmol/L group and the number of stenosal cerebral vascular was 67.Analysis of variance was conducted between the numbers of stenosal cerebral vascular of each group,the differences were significant (F =4.12,P <0.05).Conclusion In cerebral infarction patients,the incidence of Hcy(hyperhomocysteinemia) was higher than that of normal hcy.2.shows more serious damage of intracranial and extracranial arterial sclerosis occur in patients with the increase of homocysteine levels.
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<p><b>OBJECTIVE</b>To investigate the effect of electrical stimulation to sacral spinal nerve 3 (S₃ stimulation) on gastrointestinal dysfunction after spinal cord injury (SCI).</p><p><b>METHODS</b>Six rabbits were taken as normal controls to record their gastrointestinal multipoint biological discharge, colon pressure and rectoanal inhibitory reflex. Electrodes were implanted into S₃ in another 18 rabbits. Then the model of SCI was conducted following Fehling's method: the rabbit S₃ was clamped to induce transverse injury, which was claimed by both somatosensory evoked potential and motion evoked potential. Two hours after SCI, S₃ stimulation was conducted. The 18 rabbits were subdivided into 3 groups to respectively record their gastrointestinal electric activities (n=6), colon pressure (n=6), and rectum pressure (n=6). Firstly the wave frequency was fixed at 15 Hz and pulse width at 400 μs and three stimulus intensities (6 V, 8 V, 10 V) were tested. Then the voltage was fixed at 6 V and the pulse width changed from 200 μs, 400 μs to 600 μs. The response was recorded and analyzed. The condition of defecation was also investigated.</p><p><b>RESULTS</b>After SCI, the mainly demonstrated change was dyskinesia of the single haustrum and distal colon. The rectoanal inhibitory reflex almost disappeared. S₃ stimulation partly recovered the intestinal movement after denervation, promoting defecation. The proper stimulus parameters were 15 Hz, 400 μs, 6 V, 10 s with 20 s intervals and 10 min with 10 min intervals, total 2 h.</p><p><b>CONCLUSION</b>S₃ stimulation is able to restore the intestinal movement after denervation (especially single haustrum and distal colon), which promotes defecation.</p>