1.
Chinese Medical Journal
;
(24): 1585-1587, 2003.
Article
in English
| WPRIM
| ID: wpr-311626
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the K-ras mutation pattern in six pancreatic cancer cell lines from Chinese patients.</p><p><b>METHODS</b>All six cell lines were analyzed for mutation in exon 1 of the K-ras gene by polymerase chain reaction (PCR) and direct sequencing.</p><p><b>RESULTS</b>All 6 pancreatic cancer cell lines had GGT --> GTT mutation at K-ras codon 12 but no mutations at codon 13.</p><p><b>CONCLUSION</b>The unique GGT --> GTT mutation at codon 12 plays a potential role in the carcinogenesis of pancreatic cancers in Chinese.</p>