ABSTRACT
OBJECTIVE@#To investigate microvessel density (MVD) and expressions of phosphor-STAT3 and vascular endothelial growth factor (VEGF) in nasal polyps, to explore their pathogenetic correlations.@*METHOD@#All selected cases were measured up the standard of enrollment. Thirty samples of nasal polyps were obtained from patients undergoing nasal polypectomy, and 10 samples of inferior turbinate tissues were from patients undergoing nasal septal construction. p-STAT3,VEGF and MVD in nasal polyp tissues from 30 nasal polyposis patients and 10 samples of inferior turbinate tissues were detected with immunohistochemistry (sp) method.@*RESULT@#In nasal polyp tissues, The positive rates of p-STAT3 and VEGF expression were 60% and 70% respectively, all were significantly higher in nasal polyps than in control inferior turbinates (P < 0.01). MVD was significantly higher in nasal polyps than in control inferior turbinates (22.78 +/- 7.89 vs 7.12 +/- 2.84, P < 0.01). p-STAT3 expression was positively correlated with VEGF expression and MVD.@*CONCLUSION@#p-STAT3, VEGF and MVD were overexpressed in the tissues of nasal polyps, and p-STAT3 expression was positively correlated with VEGF expression and MVD; p-STAT3 was positively correlated with the neovascularization of nasal polyps, The inhibition of STAT3 pathway may inhibit the neovascularization, and then inhibit the formation and recurrence of the nasal polyps.
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Microvessels , Nasal Polyps , Metabolism , Pathology , Neovascularization, Pathologic , STAT3 Transcription Factor , Metabolism , Vascular Endothelial Growth Factor A , MetabolismABSTRACT
OBJECTIVE@#To study the distribution and expression of STAT6 and to examine the suggested roles of STAT6 in the pathogenesis of eosinophil infiltration in nasal polyps and to evaluate the role of STAT6 in the pathogenesis of nasal polyps.@*METHOD@#All selected cases met the enrollment criteria. Thirty samples of nasal polyps were obtained from patients undergoing nasal polypectomy, and 10 samples of inferior turbinate tissues were from patients undergoing nasal septal reconstruction. STAT6 in nasal polyp tissues from 30 nasal polyposis patients and 10 samples of inferior turbinate tissues were detected with immunohistochemistry (SP) method. SPSS13.0 system was used to perform the statistical analysis.@*RESULT@#The positive expression of STAT6 was significantly higher in epithelium of nasal polyps than that of the control. The number of eosinophils was significantly higher in epithelium of nasal polyps than that of the control. The difference between these two groups was statistically significant (P<0.05). STAT6 positive cell were localized on epithelium, gland cells and on inflammatory cell of nasal polyps. STAT6 expression was positively correlated with the recruitment of eosinophils in nasal polyps.@*CONCLUSION@#The high expression of STAT6 protein and the suggested roles of STAT6 in the recruitment of eosinophils in nasal polyps may contribute to the initiation and progression of nasal polyps.
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Eosinophils , Pathology , Inflammation , Nasal Polyps , Metabolism , Pathology , STAT6 Transcription Factor , MetabolismABSTRACT
Objective:To study the distribution and expression of STAT6 and to examine the suggested roles of STAT6 in the pathogenesis of eosinophil infiltration in nasal polyps and to evaluate the role of STAT6 in the pathogenesis of nasal polyps.Method:All selected cases met the enrollment criteria.Thirty samples of nasal polyps were obtained from patients undergoing nasal polypectomy, and 10 samples of inferior turbinate tissues were from patients undergoing nasal septal reconstruction.STAT6 in nasal polyp tissues from 30 nasal polyposis patients and 10 samples of inferior turbinate tissues were detected with immunohistochemistry(SP) method.SPSS13.0 system was used to perform the statistical analysis.Result:The positive expression of STAT6 was significantly higher in epithelium of nasal polyps than that of the control. The number of eosinophils was significantly higher in epithelium of nasal polyps than that of the control. The difference between these two groups was statitically significant(P<0.05). STAT6 positive cell were localized on epithelium, gland cells and on inflammatory cell of nasal polyps. STAT6 expression was positively correlated with the recruitment of eosinophils in nasal polyps.Conclusion:The high expression of STAT6 protein and the suggested roles of STAT6 in the recruitment of eosinophils in nasal polyps may contribute to the initiation and progression of nasal polyps.
ABSTRACT
OBJECTIVE@#To study the clinical significance of the expression of p53, p63 and p73 protein and the correlation of p53 and p63 in nasal and paranasal sinus carcinoma (NPSC).@*METHOD@#The immunohistochemical technique was used to detect the expression of p53, p63 and p73 in 67 cases of NPSC, para-cancer tissues and non-cancer tissues.@*RESULT@#The positive rate of p53 and p63 protein in NPSC was significantly higher than that in park cancer tissues and non-cancer tissues (P0.05).@*CONCLUSION@#There are positive correlation between p53 and p63 protein in NPSC, and they may play an important role in the tumorgenesis of NPSC. The p73 may not be associated with tumorgenesis of NPSC.
Subject(s)
Female , Humans , Male , Middle Aged , Carcinoma, Squamous Cell , Metabolism , Pathology , DNA-Binding Proteins , Metabolism , Nose Neoplasms , Metabolism , Pathology , Nuclear Proteins , Metabolism , Paranasal Sinus Neoplasms , Metabolism , Parasitology , Trans-Activators , Metabolism , Transcription Factors , Tumor Protein p73 , Tumor Suppressor Protein p53 , Metabolism , Tumor Suppressor Proteins , MetabolismABSTRACT
OBJECTIVE To investigate the rela-tionship between the expression of the proto-oncogene cerbB-2 proteins p185, level of adhesion molecules CD44v6, and lymphoid metastasis of laryngeal squa-mous cell carcinomas (LSCC). METHODS The expres-sion of p185 and CD44v6 in 63 specimen of LSCC tissues were examined by immunohistochemical method. RESULTS There was a significant difference in the expression of p185 between patient groups with and without lymphoid metastasis(P