ABSTRACT
Background: Globally 憃ral cancer� is the sixth most common cause of cancer-related death. Oral cancer accounts for approximately 30-40% of all cancers in India. The present study was conducted to assess biochemical parameters in newly diagnosed oral cancer. Methods: The present study was conducted to assess biochemical parameters in newly diagnosed oral squamous cell carcinoma. The study was conducted at GSVM Medical College, Kanpur among 196 newly diagnosed patients with oral squamous cell carcinoma and 196 healthy individuals. Serum samples from the participants were collected. The data were expressed as mean盨D. Values of p<0.001 were considered significant. Results: The present study was conducted to assess biochemical parameters in newly diagnosed oral cancer. The study was conducted at GSVM Medical College, Kanpur among 196 newly diagnosed patients with oral cancer and 196 healthy individuals. The levels of Random Blood Sugar, Serum Total Bilirubin, Direct Bilirubin, Indirect Bilirubin, Glutamic-oxalacetic transaminase (SGOT), glutamic-pyruvic transaminase (SGPT), Serum Protein, Serum Albumin, Serum Creatinine, Serum Sodium, Serum Potassium were increased in cases as compared to controls. The p-value was non-significant for all the biochemical parameters. Conclusion: The present study concluded that the levels of Random Blood Sugar, Serum Total Bilirubin, Direct Bilirubin, Indirect Bilirubin, SGOT, SGPT, Serum Protein, Serum Albumin, Serum Creatinine, Serum Sodium, Serum Potassium were increased in cases as compared to healthy controls.
ABSTRACT
Thyroid hormones are required for normal development as well as regulating metabolism in the adult. Thyroid gland disorders are the second most abundant endocrinal disorders after diabetes. A decreased thyroid hormone adversely affects erythropoietic system causes anaemia. Aim: The Aim and objective of the study was to compare the vitamin B12, Folate and Ferritin with thyroid hormones in hypothyroidism. Methods: In the present study, total 350 samples were included in which 175 were hypothyroid patients and 175 were normal individuals of age group between 15-65 years. Measurements of serum concentrations of Total T3, Total T4, TSH, Vitamin B12, Folate and Ferritin were done using Chemiluminiscence Immunosorbant Assay. Results: Serum TSH levels were significantly increased in Hypothyroidism as compared to normal individual (7.42±1.75 vs 2.72±1.28, p<0.0001*). The total T3 level was significantly decreased in Hypothyroidism in comparison to normal individual (0.43±0.41 vs 1.30±0.29, p<0.0001*). Similarly, total T4 level was significantly decrease in Hypothyroidism in comparison to normal individual (3.60±1.38 vs. 6.62±1.11, p<0.0001*). Level of Vitamin B12 was significantly decreased in Hypothyroidism in comparison to normal individual (210.45±129.30 vs 483.93±264.74, p<0.0001*). Folate was significantly decreased in Hypothyroidism as compared to normal (2.51±0.99 vs 6.67±0.83, p<0.0001*). Ferritin was also observed significantly decreased in Hypothyroidism in comparison to normal (23.08±1.18 vs 63.43±3.30, p<0.0001*). TSH was observed significantly correlated with Folate (r=0.187* p=0.013). Conclusion: The Lower values of above these parameters in hypothyroidism interpret that thyroid hormones are metabolic hormones and produce impact on our metabolic and hormonal balance in which hemopoetic system is highly effected.
ABSTRACT
Introduction: Acute myocardial infarction is a leading cause of death throughout the world. Myocardial infarction is defined as myocardial cell death due to prolonged ischemia. Objectives of the study were to look for the role of inflammatory markers (CRP, IL-6, and plasma fibrinogen) in the prediction of myocardial infarction. In recent times, IL-6 and plasma fibrinogen are not established marker in acute myocardial infarction. However, there is another biomarker i.e. CRP that have shown additional value in improving sensitivity and prognostic information. Novel biomarkers have improved assessment of outcome in acute myocardial infarction, but none have been demonstrated to alter the outcome of a particular therapy or management strategy. Thus the finding of this study may help the clinician to develop more novel therapeutic strategies for the management of myocardial infarction (MI) patients. The outcome of the study will be very beneficial as well, to the researcher working in the concerned area in order to develop more focused research approach