ABSTRACT
Background: Gestational diabetes mellitus is defined as any glucose intolerance with the onset or first recognition during pregnancy. Objectives of this study were to diagnose cases of GDM by screening with DIPSI criteria at less than 28 weeks. And observation and comparison of maternal and perinatal outcome in women diagnosed of GDM in less than 20 weeks and at 24-28 weeks.Methods: This was the prospective analytical study conducted in the department of obstetrics and gynecology for one year in Muzaffarnagar medical college and Hospital. After history taking, clinical and obstetrics examination 1503 antenatal patients of less than 28 weeks were enrolled underwent screening with DIPSI criteria. Out of which 80 patients with abnormal OGTT of gestational age less than 20 weeks and 69 patients with abnormal OGTT of gestational age 24 -28 weeks.Results: In early diagnosed GDM group alive and healthy babies were slightly lower as compared with late diagnosed GDM group.Conclusions: The diagnosis of GDM gives us an opportunity in identifying individuals who will be benefitted by early therapeutic intervention with diet, exercise, and normalizing the weight to delay or prevent the onset of the disease.
ABSTRACT
Background:Oral contraceptives can induce changes in lipid, lipoprotein and carbohydrate metabolism. This study is done to find out basal lipid profile in females of reproductive age group using sequential hormone therapy and with low dose estrogen combinations pills; and to study the changes in lipid profile after 3 months use of sequential hormone therapy and with low dose estrogen combination pills. Methods: Total 40 females were taken of 18-40years of reproductive age group ,subjects were divided into two groups. Group A: 20 females were subjected to sequential hormones therapy. Group B: 20 females were subjected to combined oral contraceptive pill “Mala N”. Results: In Group A there was significant rise in serum cholesterol, serum TGs ,LDL, VLDL levels and LDL:HDL ratio. HDL shows fall in there levels. In Group B there was no significant change in all lipid parameters. Conclusion: There is substantial degree of metabolic changes in lipid lipoprotein profile in females with use of sequential hormones .With use of low dose estrogen and progesterone pills, there is no such deleterious effect on lipid profile and so it can be used for prolonged period. As the indications of use of sequential hormones in females of reproductive age group are now increasing in gynecological practice it would be advisable to decrease the dose of estrogen to avoid its effects on lipid profile