Analgesic and antiinflammatory activity of methanolic extract of acalypha indica linn

Previous phytochemical analysis of methanolic extract of Acalypha indica L. has indicated the presence of steroid, flavonoid and terpenoid types of compounds. Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine, prompted us to check A. indica L. for possible analgesic and antiinflammatory activities. The methanolic extract of A. indica L. showed statistically significant [P<0.001] analgesic activity in mice in a dose-dependent manner. A sustained and significant [P<0.001] inhibition of carrageenan-induced inflammation of rat paw was observed with 125 mg/kg and 250 mg/kg body weight. The methanolic extract of A. indica L. also demonstrated antiinflammatory effect in a dose-dependent manner. Maximum inhibition by the extract was observed at 250 mg/kg body weight after three hours of ingestion, which was comparable to that of the standard drug phenylbutazone at a dose of 100 mg/kg body weight. The obtained results provide a support for the use of this plant in traditional medicine

Anti inflammatory activity of indanyltetrazole derivatives

A number of indanyl tetrazolederivatives namely 5-[6'-chloroindan-1'-yl]tetrazole [CIT], 5-[6'-bromoindan-1'-yl]tetrazole [BIT], 5-[6'-chloroindan-1'-yl]methyltetrazole [CIMT], 5-[6'-bromoindan-1'-yl]methyl-tetrazole [BIMT] were evaluated for the anti-inflammatory activity in carragennan induced rat paw edema in Swiss albino Wister rats for 24-hour period at the dose of 100 mg/kg of body weight by intraperitoneal route where phenylbutazone [PBZ] was used as the standard. All of these compounds exhibited inhibition on rat paw edema with peak actions observed following 3 hours after administration. Moreover, compounds CIMT and BIMT were further evaluated at dose of 50 mg/kg of body weight. Among the compounds, CIMT showed higher activity than others and was very close to standard phenylbutazone