ABSTRACT
Introduction: Endoscopic tympanoplasty is a minimalinvasive surgery, causing minimal trauma to healthy tissue.The other advantages are speculum which narrows canal canbe avoided, there is no frequent tilting of head, no seepageof blood into graft bed and no fear of perichondritis. Currentresearch aimed to study the advantages and disadvantagesof endoscopic tympanoplasty and to study the limits andlimitations of endoscopic tympanoplasty in relation to theanatomy and disease.Material and Methods: This study includes evaluating 35cases of endoscopic tympanoplasty with follow up period of 4months study was prospective study performed. Patient of age(18-50years) and both sexes with CSOM inactive stage withconductive deafness who require surgical intervention wereincluded in our study and patients with the External auditorycanal width is less than 6 mm were excluded in this study.Results: In our Study out of 35 patients, 8 (23%) patientsshowed Small Central Perforation, 4 cases showing perforationin antero-inferior quadrant and 4 cases showing perforationin postero-inferior quadrant), 19 (54%) patients showed largecentral perforation and the remaining 8 (23%) showed SubTotal Perforation.Conclusion: The Trans-canal endoscopic tympanoplasty isthe procedure of choice for chronic suppurative otitis mediaof tubo-tympanic type in inactive stage (Inactive mucosalchronic otitis media) with Grade 2 and Grade 3 canals.
ABSTRACT
For understanding the molecular mechanism one can also adopt in silico approach where the interactions such as Protein-protein interactions, Protein-compound interactions, DNA-compound interactions, DNA-protein interactions are commonly used. Here we focused on the fate of these interactions for some of the compounds of Emblica officinalis with normal DNA polymerase β. Efficacy of these compounds involves design/taking from the databases of these molecules that are probable to act on the bimolecular target. DNA polymerase beta protein PDB (1DK3) was used to dock with compounds like Quercetin, Myricetin and 3,7,3,4-Tetra Hydroxy Flavone. All these compounds showed best binding studies with DNA polymerase beta.