A Case of Cavernous Hemangioma Arising from Left Vocal Cord / 대한이비인후과학회지

Hamangioma of the larynx is generally classified into adult and infantile form. Infantile hemangiomas can be frequently seen in the subglottic area and has a self-limited disease course while adult hemangiomas are rare and can be seen in different locations such as in epiglottis, aryepiglottic fold, arytenoid and false and ture vocal cords. They are more often of cavernous form. Authors experienced a case of cavernous hemangioma at the left vocal cord in a 48 years-old-man, so we report this case with a review of the literature.

A Case of Papillary Cystadenocarcinoma Arising from Submandibular Gland / 대한이비인후과학회지

Papillary cystadenocarcinoma originated from salivary gland is a lower grade neoplasm that rises most commonly in major salivary glands, although involvement of lip, palate, buccal mucosa and tongue has also been described. Papillary cystadenocarcinoma was first defined in 1991 by WHO. Until then, it was classified as an atypical type of adenocarcinoma. We experienced a case of papillary cystadenocarcinoma of the submandibular gland, so we report this case with a review of the literature.

Two Cases of Stroke with False Lateralization in EEG Mapping

In recent days quantitative electroencephalography (QEEG) has grown rapidly and QEEG techniques and EEG mapping have shown localizing functional imaging. We report two cases of falsely lateralized EEG mapping in stroke patients. Both cases had right hemispheric stroke, but presented bilateral clinical symptoms. Contrary to structural imaging, EEG mapping displayed left hemispheric dysfunction and SPECT displayed bilateral perfusion Aegects. These findings suggest that false lateralization of EEG mapping in unilateral stroke patients may show bilateral cerebral dysfunction not detected in conventional imaging technique.

A Case of Metastatic Hepatocellular Carcinoma of the Ethmoid Sinus / 대한이비인후과학회지

Hepatocellular carcinoma usually metastasizes to lung, breast, lymph node, GI tract, bone, kindey, and adrenal gland. Up to now, only few cases of hepatocellular carcinoma presenting as a metastatic ethmoid sinus tumor could be found in the literature. If a patient with hepatocellular carcinoma complains epistaxis, and if expansile, osteolytic, and hypervascular lesions are observed in a radiologic examination, nasal cavity and sinus tumor should be confirmed through biopsy. We report, along with the review of appropriate literature, a case of histollogically confirmed metastatic hepatocellular carcinoma of the ethmoid sinus of a 56 year old man.

Imaging and Acoustic Study of Laryngectomees after the Amatsu Tracheoesophageal Shunt Operation / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: The two most important methods for voice rehabilitation after total laryngectomy are tracheoesophageal speech and esophageal speech. The former can be obtained in several ways, for example, by the primary Amatsu tracheoesophageal (T-E) shunt operation or by the use of a low-resistance valve such as the Provox prosthesis. The purpose of this investigation was to study the anatomy and physiology of the neoglottis and to evaluate the vocal quality of tracheoesophageal speech. MATERIALS AND METHODS: A total of 12 patients, who had undergone the Amatsu T-E shunt operation after total laryngectomy, were analyzed using the stroboscopy, laryngofiberscopy, videofluoroscopy, and computerized speech lab. RESULTS: With stroboscopy, the neoglottis was split from left to right in 3 patients and in 9 patients, the direction of opening and closure of rheeoglottis was anterior-posterior. The regular vibratory features were observed in patients with a shortened visible vibratorvsegment. The results of videofluoroscopy indicate that the location of the vibration was mostly situated between C3 and C5. The cervical esophagus closure during tracheoesophageal phonation was located at a level between C7-T2. CONCLUSION: The anatomical and morphological characteristics of the neoglottis was related to the healing process after operation. The neoglottis was considered to be formed by the thyropharyngeal muscle, and concentric contraction under subneoglottic extension was formed by the contraction of the cervical esophagus.

A Case of Primary Malignant Melanoma in Parotid Gland / 대한이비인후과학회지

Reports on primary malignant melanoma arising from parotid gland are extremely rare. We report a case of malignant melanoma which was presented in the parotid gland with no other primary lesions detectable. The main clinical presentation was a progressively enlarging, asymptomatic mass in the parotid gland. The 29-year-old patient underwent a total parotidectomy and right modified radical neck dissection type I. The patient was subsequently treated by postoperative high-dose radiotherapy. The most common symptom of primary malignant melanoma in the parotid gland is a progressively enlarging, asymptomatic, firm, and fixed mass. Radical excision is the treatment of choice. The role of radiotherapy, chemotherapy and immunotherapy remains unclear. Although rare, primary malignant melanoma should be considered in the differential diagnosis of parotid gland tumor. We report the case with a review of the literature.

Expression of MAGE 3 Gene Product in Squamous Cell Carcinomas of the Head and Neck / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: MAGE 3 gene may constitute a potential target for cancer immunotherapy since it is expressed in a variety of cancers but not in normal tissues except the testis. In this study, expression and intracellular location of MAGE 3 gene products were investigated using squamous cell carcinomas of the head and neck. MATERIALS AND METHODS: MAGE 3 protein expression was screened in 40 squamous cell carcinomas, 2 tumor lines, 20 benign diseases, and 20 normal tissues of the head and neck. Immunohistochemical staining with anti-MAGE 3 mAb 57B was conducted from fresh frozen specimens. A correlation between MAGE 3 expression and clinicopathological parameters was also evaluated. RESULTS: MAGE 3 gene product was detected in squamous cell carcinomas (18/40, 45%) and in tumor lines (2/2, 100%), but not in benign diseases and normal tissues. MAGE 3 gene product was identified as a cytoplasmic protein of cancer cells without staining in normal epithelia and stromal tissues coexisting adjacent to cancer cells. No significant correlation between MAGE 3 expression and clinicopathological parameters including tumor cell differentiation, age, gender, primary site, tumor stage, and metastasis was drawn. CONCLUSIONS: MAGE 3 antigen could represent a potential target for immunotherapy in head and neck squamous cell carcinomas.