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Indian J Lepr ; 1988 Jul; 60(3): 363-73
Article in English | IMSEAR | ID: sea-55221

ABSTRACT

In the present work we report our studies on IgG separated from the serum of lepromatous patients and non-lepromatous leprosy cases using Laser Raman Spectroscopy. Striking spectral changes in LL cases have been observed in the following special regions: (a) the amide I and III, (b) the S-S and C-S stretching (c) the skeletal bending and (d) skeletal stretching regions. These changes indicate a decrease in the amount of beta-structure and a transition towards alpha-helical conformation.


Subject(s)
DNA-Binding Proteins/blood , Humans , Immunoglobulin G/analysis , Lasers , Leprosy, Lepromatous/blood , Mass Spectrometry , Protein Conformation , Stereoisomerism
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