ABSTRACT
To compare the efficacy and safety of magnesium sulphate in 12 hours regime versus 24 hours regime after last fit in eclamptic patients. Randomized controlled trial study. This randomized controlled trial was carried out at Department of Obstetrics and Gynaecology, Unit-Ill, Nishtar Medical College/Hospital Multan from 01.06.2013 to 31.05.2014. Total 120 patients with eclampsia were included. All patients were given 4g of magnesium sulphate [20% solution] intravenously slowly [15 mins] as loading dose. After receiving the loading dose randomization was performed by block design. So 60 patients for 12 hour regime while 60 patients for 24 hour regime [control group]. In 12 hour regime group magnesium sulphate maintenance dose of Ig [20% solution] was given 1 hourly intravenously for 12 hours after last fit. In 24 hour regime group magnesium sulphate maintenance dose of ig [20% solution] was given 1 hourly intravenously for 24 hours after last fit. Efficacy in shape of recurrence of fits, number of fits and safety in shape of pulmonary oedema, oliguria and loss of knee jerk reflex,Nausea and flushing was noted. Total 120 patients were studied falling in age group of 20 to 40 years. Eclampsia was most commonly occurring in young and primigravida patients. Majority of eclamptic patient had diastolic B.P 110 or > 1 l0mmHg. None of patients in either group had eclamptic fit. Loss of knee jerk reflex seen in 5 patients in 24hrs regime group. Minor side effects were more commonly observed in 24hrs regime group. [n=38] of the students were underweight and 36 % [n=21] were obese. Twelve hours regime is equally effective as 24hours regime but with lesser side effects and so more cost effective. 12hours regime was observed to promote shorter hospital stay decreasing work load
Subject(s)
Humans , Adult , Female , Magnesium Sulfate/pharmacology , SafetyABSTRACT
To determine the frequency of live birth in patients with unexplained recurrent abortions treated with low molecular weight heparin and aspirin. Descriptive study. This study was carried out at Department of Obstetrics and Gynaecology, Unit-Ill,Nishtar Medical College and Hospital, Multan from 01.01.2014 to 31.12.2014. Sixty women with past history of two or more previous unexplained recurrent abortions who received low-molecular weight heparin [LMWH] and low dose aspirin [LDA] were included in the study and followed subsequently for the pregnancy outcome in the form of live birth measure. The age range between 20 to 40 years with mean 32.38 +/- 3.64 years. A total of sixty patients were studied with a 58.3% patients were belong to age group of 31-35 years. Previous abortion percentage was 36.7% with 2 abortions while 63.3% with 3 abortions with mean 2.63 +/- 0.49 abortions. Live birth was recorded in 51 out of 60 patients with percentage of 85%. An enhancement in the live-birth rate was observed after low-molecular weight heparin [LMWH] and low dose aspirin [LDA] administration, in patient with 2 or more consecutive unexplained recurrent abortions