ABSTRACT
Squamous cell carcinoma of oral cavity is of malignant tumors, which causes cancerous complications. DNA damage, mainly because of products of oxidative stress like reactive oxygen species, is a frequent mutagenic that triggers carcinoma. Smoking increases the probability of cancer incidence. Saliva is the first biological medium to interact with external compounds, especially smoking substances. The present study overviews the salivary level of some remarkable compounds in relation with smoking and squamous cell carcinoma
To collect data, English literature was searched in databases including PubMed, Sci-enceDirect and Google Scholar. The keywords used for search were as follows: 'Carcinoma, Squamous Cell', 'Smoking', 'Saliva', and 'Biomarkers
The inclusion criteria were the presence of salivary chemical factors in relation with oral cancer and influence by smoking. Out of 239 found articles, only 56 were selected. Our results demonstrated the potential role of salivary biochemistry to predict and/or treat complications with cancer in both smoker and non-smoker individuals. Changes in concentrations of salivary chemicals including antioxidants, total antioxi-dant, glutathione and uric acid, epithelial growth factor, cytokine biomarkers, super-oxide dismutase activity, and transcriptome were related to squamous cell carcinoma and could be used as potential biomarkers for cancer prognosis; moreover, enhance-ment of antioxidant level might be a potential treatment
Subject(s)
Carcinoma, Squamous Cell , Smoking , Saliva , Biomarkers , Smokers , Review Literature as TopicABSTRACT
Lichen planus is a chronic inflammatory mucocutaneous disease with immune system's origin. There is no definite cure for that and present treatment methods are symptomatic. According the effects of topical medications and anti-inflammatory properties of licorice, this study is designed for comparison the effectiveness of the adhesives containing licorice with topical steroid on treatment of oral lichen planus. In this double-blind clinical trial, 40 patients randomly divided into two groups: licorice and topical corticosteroid therapy and were followed up for 12 weeks, we asked patients used the drugs four times in a day and after applying drugs avoid of eating, drinking and smoking for an hour. Data were analyzed by SPSS-19, using the independent samples t-test and Mann-Whitney U tests. In this study the use of topical licorice as topical corticosteroids were effective in reducing pain, but the improvement of clinical signs was not effective as corticosteroids. The severities of lesion according Thongprasom classification were 1.2 +/- 1.03 in corticosteroid group and 2.6 +/- 0.9 in licorice group. There was a statistical significant difference between groups [p=0.006]. Based on the findings of this study topical licorice 5% is not a good alternative for topical corticosteroids in the treatment of lichen planus
ABSTRACT
The aim of the present study was to compare hematologic problems in patients with recurrent aphthous stomatitis, with a control group. In this cross sectional study, 30 subjects with recurrent aphthous stomatitis and 30 healthy individuals were included as the case and control groups, respectively. After diagnosis was established a 10 ml sample of the subjects' blood was used to determine serum levels of iron, ferritin, vitamin B12, folic acid and zinc in each subject. Independent t-test was used to analyze data. The average serum iron, serum ferritin, vitamin B12, folic acid and serum zinc levels in the case and control groups were assessment, demonstrating no statistically significant differences between the two groups [p>0.05]. According to the results of the present study, hematologic deficiencies cannot play a role in etiology of aphthous stomatitis
ABSTRACT
Oral lichen planus [OLP] is a chronic immunological disorder with unknown etiology. The aim of this study was to determine psychological factors and salivary cortisol, IgA level in patients with oral lichen planus. In this experimental study 20 patients with OLP and healthy person were admitted to this study. Saliva samples were collected between 9-10 Am. saliva cortisol, IgA level was detected by ELIZA method. In this study, patients with anxiety and depression were measured using the SCL-90 questionnaire. Data analyzed by t-test. The mean salivary cortisol level in patients with OLP was 3.2 +/- 1.9 ng/mL and the mean saliva cortisol level in healthy person was 3.5 +/- 1.9 ng/mL. Significant difference was observed in the salivary cortisol levels in the 2 study groups [p=0.04]. The mean salivary IgA level in patients with OLP was 0.69 +/- 0.29 ng/mL and the mean saliva IgA level in healthy person was 0.9 +/- 0.43 ng/mL but no significant difference was observed in the salivary cortisol levels in the 2 study groups. Results showed that anxiety levels in patients with oral lichen planus were slightly higher than controls but there was no significant difference between healthy subjects. Finding revealed the mean salivary cortisol level in patient with OLP less than healthy persons. Significant difference was observed in the salivary cortisol levels in the 2 study groups. Based on the t-student test, no significant difference was observed in the salivary IgA levels in the 2 study groups. Anxiety levels in patients with oral lichen planus were slightly higher than controls
ABSTRACT
Central giant cell granuloma, [giant cell reparative granuloma], is a non-neoplastic proliferative lesion with unknown etiology which commonly occurs in the mandible. This lesion presents a wide variety of radiological and clinical manifestations that may lead to misdiagnosis. CGCG is diagnosed through histopathological examinations
ABSTRACT
Neurofibroma is a benign neoplasm derived from peripheral nerve cells. Neurofibroma can occur as a solitary tumor also it may associate with neurofibromatosis. Intraosseous neurofibroma is a rare tumor particularly in the oral cavity. So far, few cases of solitary intraosseous neurofibroma of the mandible have been reported. In the present study, a 39 years old woman which has a diagnosis of solitary intraosseous neurofibroma of the mandible is reported. Clinical, radiographic, histopathologic and immunohistochemical features are described
ABSTRACT
Pyostomatitis vegetans [PV] is a rare chronic inflammatory disease of unknown etiology. Oral appearance are the first symptoms. One of the less common clinical features is erosions which tend of form granulation tissue, and finally develop a vegetative looking, especially in the skin folds and heal and face. In clinical examination diffuse vegetation and snail tract was found
Subject(s)
Humans , Female , Lip/pathology , Cheek/pathologyABSTRACT
Odontogenic tumors constitute an important aspect of oral and maxillofacial pathology. Frequency of odontogenic tumors varies in different societies but no study has been done in Zahedan so far. The purpose of this study was to achieve the sex, location and age distribution of odontogenic tumors and frequency of each one in a period of ten years. In this study, documents in archive of maxillofacial pathology department of Zahedan dental school, Khatamolanbia, Tamin ejtemaei Hospital and private laboratories were reviewed from 2000 to 2010. Data about age, sex, location of tumors and relation with impacted tooth were extracted and were submitted in the forms. In this study, among the 1125 cases of the oromaxillofacial lesions, 50 cases of odontogenic tumors were found. Among the different tumors, keratocyst odontogenic tumor [KOT] was the most common odontogenic tumor [48%], followed by ameloblastoma and odontoma with frequency of 24% and 12%, respectively. There were no cases of malignancy. The incidence of these lesions was 52% in women and 48% in men. The most common location of tumors was posterior of mandible and tumors were more frequent in the third decade of life. In 12 cases, the lesions were accompanied by impacted teeth. In this study the most frequent tumors were KOT, Ameloblastoma and odontoma respectively.