ABSTRACT
BACKGROUND AND AIMS: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of histiocytes characterized by a proliferation of abnormal and clonal Langerhans cells. We retrospectively studied clinicopathologic features of this disorder in five cases. METHODS: Clinical and histopathological findings of five cases of cutaneous LCH were reviewed based on the hospital records. RESULTS: The age of patients ranged from 28 days to 5 years and M: F ratio was 1:1.5. Clinically, the diagnoses suggested were histiocytosis, varicella, transient neonatal pustular melanosis, keloid, sarcoidosis, seborrheic keratosis and LCH. The most common type of skin lesion was a generalized papular lesion. Histologically, all cases showed aggregates of large mononuclear histiocytes (Langerhans cells) with reniform, irregular, cleaved nuclei and abundant eosinophilic cytoplasm. There was multi-systemic involvement in two patients and single-system involvement in three patients. CONCLUSION: Cutaneous lesions may be the sole presenting feature of LCH. Diagnosis is based on demonstration of S-100 positive histiocytes.
Subject(s)
Adult , Child, Preschool , Female , Histiocytosis, Langerhans-Cell/diagnosis , Humans , Infant , Infant, Newborn , Langerhans Cells/pathology , Male , Retrospective Studies , Skin/pathologyABSTRACT
Nonpuerperal breast abscess (NPBA) has different etiology as compared to the mastitis occurring in post partum women. The condition presents either as acute suppurative infection or chronic type. Organisms usually implicated are Staphylococcus aureus, coagulase negative staphylococci, and anaerobes. Mostly the infection is polymicrobial in nature. Herein, we report the isolation of Enterococcus faecalis from a case of acute suppurative NPBA.
Subject(s)
Abscess/diagnosis , Breast Diseases/diagnosis , Diagnosis, Differential , Enterococcus faecalis/isolation & purification , Female , Gram-Positive Bacterial Infections/diagnosis , Humans , Mastitis/diagnosis , Middle Aged , Puerperal Infection/diagnosisABSTRACT
Urticarial vasculitis is an uncommon manifestation of cutaneous vasculitis closely resembling chronic urticaria. It is an immune complex deposition disorder, which is not commonly observed in children. We report an 9-month-old infant with urticarial vasculitis and discuss its clinical course and differentiation from common urticaria.
ABSTRACT
Intralesional steroids are commonly used in dermatology. Besides their strong anti-inflammatory effects, the long acting steroids and other preservative agents may induce interesting histopathological changes, which may simulate focal mucinosis or a granulomatous pathology. A variety of histopathological changes induced by Intralesional injection of steroid in a lesion of keloid are being described.
ABSTRACT
Basal cell carcinoma is a common cutaneous malignancy, frequently occurring over the face in elderly individuals. Various therapeutic modalities are available to treat these tumors. We describe three patients with basal cell carcinoma successfully treated with cryosurgery and discuss the indications and the use of this treatment modality for basal cell carcinomas.
ABSTRACT
Nevomelanocytic nevi exhibit clinical variations in morphology, location, texture and number related to age, race and geographical distribution. Development of age related greying of hair over pigmented melanocytic nevus is being discussed.
ABSTRACT
Pilomatricoma (calcifying epithelioma of Malherebe) is an uncommon skin tumour that occurs predominantly in young people. No studies are available from the Indian subcontinent on pilomatricoma. We analyzed records of 18 cases of pilomatricoma seen during 5 years period (1995-99). There were 16 females and 2 males and their age ranged from 5 to 60 years. All patients had solitary lesions in 10 out of 18 cases (55.5%), the tumour was located in head and neck region including 5 cases (27%) where it involved orbital margin and eye-brow. In only 2 out of 18 cases, a clinical diagnosis of pilomatricoma was suggested. In addition to the secondary changes described in previous studies, we observed additional changes like myxoid change, oedema fluid and necrosis with karyorrhectic debris in few of these tumours. Making a clinical diagnosis of pilomatricoma can be difficult. The final confirmation is by histopathological examination only.
Subject(s)
Adolescent , Adult , Child , Child, Preschool , Female , Head and Neck Neoplasms/diagnosis , Humans , Male , Middle Aged , Pilomatrixoma/diagnosis , Retrospective Studies , Skin Neoplasms/diagnosisSubject(s)
Alopecia Areata/genetics , Chromosome Aberrations , Diagnosis, Differential , Genes, Dominant , Hair/abnormalities , Humans , Infant , MaleABSTRACT
A case of acute viral hepatitis B with features suggestive of infectious mononucleosis in a 20 year girl is described. A differential diagnosis of heterophil negative infectious mononucleosis like syndrome due to varied aetiology based on serology is emphasised.