ABSTRACT
Male albino rats weighing between 150-225 gm fasted over night but freed having water ad libitum were used to assess the diuretic efficacy of intramuscular aminophylline and frusemide separately and concurrently after intraperitoneal 10 ml of distilled water loading. The normal rate of diuretic weight loss was less augmented by aminophylline and more augmented by frusemide. The diuretic response was more by the concurrent intramuscular administration of aminophylline and frusemide in comparison with that due to either drug alone. However, the observed diuretic response of the two drugs administered concurrently was lesser (infraadditive) than the sum of the individual diuretic response (additive).
Subject(s)
Aminophylline/pharmacology , Animals , Body Weight/drug effects , Diuretics/pharmacology , Drug Interactions , Furosemide/pharmacology , Male , RatsSubject(s)
Adult , Diet, Vegetarian , Dyskinesia, Drug-Induced/etiology , Female , Humans , Male , Metoclopramide/adverse effects , Middle Aged , Vomiting/drug therapySubject(s)
Animals , Electrocardiography , Female , Garlic , Injections, Intravenous , Male , Plants, Medicinal , RatsABSTRACT
Parachloromercury benzoate (PCMB), a sulphydryl inactivator, caused a progressively increasing inhibition of tissue responses to acetylcholine, adrenaline, noradrenaline and serotonin in vitro. This inhibition was progressively and completely reversed by penicillamine, a sulphydryl activator. It is inferred that intact sulphydryl groups are essential for constancy of responses of excitable tissues to the neurotransmitters.
Subject(s)
Acetylcholine/pharmacology , Animals , Chloromercuribenzoates/pharmacology , Epinephrine/pharmacology , Muscle Contraction/drug effects , Norepinephrine/pharmacology , Penicillamine/pharmacology , Rabbits , Rats , Serotonin/pharmacology , Sulfhydryl Compounds/pharmacology , p-Chloromercuribenzoic AcidSubject(s)
Acetaminophen/pharmacology , Adult , Blood Pressure/drug effects , Drug Interactions , Heart Rate/drug effects , Humans , Male , Middle Aged , Posture , Sotalol/pharmacologySubject(s)
Animals , Body Weight , Diuresis/drug effects , Furosemide/antagonists & inhibitors , Male , Phenytoin/pharmacology , Rats , Rats, Inbred StrainsABSTRACT
Benzamido (alkyl) methyl pyrrolidine Mannich bases were synthetized and subjected to certain neuropharmacological studies. All the bases reduced the pentobarbitone sleeping time and rota-rod grip of rats. The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. The TAB-induced pyrexia was not reduced by the bases I and III in rabbits. None of the bases showed any significant analgesic activity.