Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Pregnancy , Young Adult , Influenza A Virus, H1N1 Subtype , Influenza, Human/virology , Age Factors , Chile/epidemiology , Hospitalization/statistics & numerical data , Influenza, Human/diagnosis , Influenza, Human/epidemiology , Severity of Illness Index , Young AdultABSTRACT
Introduction: The new pandemic influenza A H1N1 2009 virus has shown a different clinical behavior in different age groups. Objective: To describe the clinical features of adult patients hospitalized with influenza AH1N1 2009 and compare the clinical and demographic variables among adults < 50 years and over 50 years old. Patients and Method: We included hospitalized patients between May 17 and July 17, 2009 confirmed by polymerase chain reaction (PCR) and/or rapid test for influenza A. Results: 124 patients were hospitalized with a median age of 33 years (range: 15-82 years). 36 percent had comorbidities and the main symptoms were fever, cough, myalgia and sore throat. There were 16 cases with pneumonia. From 124 patients, 77 percent were A-49 and 23 percentA-50, with comorbidity of 21 percent and 86 percent, respectively. There were no fatalities. Conclusions: Hospitalized patients had mild to moderate disease, a benign course and short hospitalization stay. There were more hospitalizations in A-49 and higher comorbidity in A-50.
Introducción: El nuevo virus influenza AH1N1 2009 ha mostrado un comportamiento clínico diferente en distintos grupos etáreos. Objetivo: Describir las características clínicas de los pacientes adultos hospitalizados con influenza A H1N1 2009 y comparar las variables clínicas y demográficas entre menores y mayores de 50 años. Pacientes y Método: Se incluyeron los pacientes hospitalizados entre el 17 de mayo y 17 de julio del 2009 confirmados por reacción de polimerasa en cadena (RPC) y/o pruebas rápidas para influenza A. Resultados: Se hospitalizaron 124 pacientes con una mediana de edad de 33 años (rango: 15-82 años). Un 36 por ciento presentó co-morbilidad y los síntomas principales fueron: fiebre, tos, mialgias y odinofagia. Hubo 16 casos con neumonía. Del total, 77 por ciento fueron < 50 y 23 por ciento ≥ 50 años. Tenían co-morbilidades 21 por ciento en el grupo < 50 versus 86 por ciento en ≥ 50 años. No hubo casos fatales. Conclusiones: Los pacientes presentaron una enfermedad leve a moderada, de curso benigno y corta hospitalización. Hubo más hospitalizados en < 50 y mayor co-morbilidad en ≥ 50 años.
Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Pregnancy , Young Adult , Influenza A Virus, H1N1 Subtype , Influenza, Human/virology , Age Factors , Chile/epidemiology , Hospitalization/statistics & numerical data , Influenza, Human/diagnosis , Influenza, Human/epidemiology , Severity of Illness Index , Young AdultSubject(s)
Adult , Humans , Respiratory Syncytial Virus Infections , Respiratory Syncytial Virus, Human , Respiratory Syncytial Virus Infections/diagnosis , Respiratory Syncytial Virus Infections/virology , Respiratory Syncytial Virus, Human/genetics , Respiratory Syncytial Virus, Human/immunology , Respiratory Syncytial Virus, Human/isolation & purification , Reverse Transcriptase Polymerase Chain Reaction/methods , Reverse Transcriptase Polymerase Chain Reaction/standards , Sensitivity and SpecificityABSTRACT
La necrosis retinal aguda (NRA) es una afección grave que amenaza la visión. Se describe en adultos, en especial aquellos profundamente inmunocompro-metidos, como consecuencia de la reactivación de virus del grupo herpes. Presentamos un paciente de 4 años de edad, con una leucemia de alto riesgo, que durante una quimioterapia intensa desarrolló una varicela con compromiso visceral, incluyendo la retina, lo que le causó ceguera unilateral. En el humor vitreo se detectó ADN de virus varicela-zoster, pese al tratamiento con aciclovir. La visión del ojo contralateral permaneció indemne.
Acute retinal necrosis (ARN) is a serious condition that can impair vision. It mostly occurs in adult patients, especially those severely immunocompromised, in association with a reactivation of a herpes virus infection. We present a 4 years old patient with high risk acute leukemia, whom during a course of intense chemotherapy acquired chickenpox with visceral involvement that affected the retina, causing unilateral blindness. Varicella-zoster virus was detected by PCR in the vitreous humor, in spite of previous acyclovir treatment. The contralateral vision remained undamaged.
Subject(s)
Child, Preschool , Humans , Male , Chickenpox/complications , Immunocompromised Host , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Retinal Necrosis Syndrome, Acute/virology , Antiviral Agents/therapeutic use , Chickenpox/diagnosis , Chickenpox/drug therapy , Retinal Necrosis Syndrome, Acute/diagnosis , Retinal Necrosis Syndrome, Acute/drug therapyABSTRACT
La necrosis retinal aguda (NRA) es una afección grave que amenaza la visión. Se presenta en adultos, en especial aquellos profundamente inmunocompro-metidos, como consecuencia de la reactivación de virus del grupo herpes. Se revisan la entidad clínica de la NRA, su diagnóstico nosológico y etiológico, como el manejo recomendado actualmente.
Acute retinal necrosis (ARN) is a serious condition that can impair vision. It mostly occurs in adult patients, especially those severely immunocompromised, in association with a reactivation of a herpes virus infection. Clinical and ophtalmological features of ARN and recommended diagnostic and management strategies are reviewed.