ABSTRACT
Los aneurismas se definen como dilataciones localizadas y permanentes que suponen un incremento del calibre del vaso mayor del 50%. En la carótida interna son poco frecuentes, de etiología casi siempre aterosclerótica y aparecen con mayor frecuencia en mujeres mayores de 60 años. La porción cavernosa de la arteria carótida interna raramente sufre ruptura y tiene una clínica variada que incluye cefalea, diplopía, parálisis de los nervios oculomotores y dolor facial. Presentamos el caso clínico de un paciente del Hospital Vargas de Caracas con aneurisma gigante de arteria carótida derecha en seno cavernoso, quien inició de forma súbita cefalea holocraneana, acompañada de oftalmoplejía, midriasis, disminución de la agudeza visual y sin signos de irritación meníngea, que se manejó de forma médica conservadora con evolución satisfactoria
Aneurysms are defined as permanent expansions of the artery with an increase of arterial blood of 50 %. The ethiology is mostly atherosclerotic, and they appear more frequently in 60-year old women. The clinical presentation is more frequent with migraine, diplopya, paralysis of the oculomotor nerves and facial pain. We present a case of a patient with a gigantic aneurysm of the cavernous sinus of the carotid artery treated at the Hospital Vargas de Caracas, Venezuela. This patient had a sudden severe migraine, accompanied of ophthalmoplegia, mydriasis, impaired vision, without signs of meningeal irritation. The treatment was medical with satisfactory progress of the patient
Subject(s)
Humans , Male , Aged, 80 and over , Intracranial Aneurysm/diagnosis , Aneurysm/diagnosis , Carotid Arteries/pathology , Cavernous Sinus/abnormalities , Vision, Low/pathology , Headache/pathology , Diplopia/pathologyABSTRACT
Infectious diseases leishmaniosis among them, constitute a leading cause of death world wide, especially in the developing world, where they remain as an important cause of concern and has become a serious problem because of the everyday enhanced risk of co infection with HIV and the increasing frequency of resistance development of the parasites to the drug agents. Emergence of drug resistance is usually associated with changes in the expression of an specific membrane P-glycoprotein, but also includes physiological responses with high complexity. In the present review we summarize results which emphasize that the comprehesion of the molecular pharmacology of drug-resistant phenotype must include, as a way for identifying new strategies for the control of the disease, the understanding of the multiple biochemical and functional parasite mechanisms involved