ABSTRACT
One hundred thirty-four lung cancer cases who were histologically proven in life and who had chest x-rays at time of initial diagnosis were entered into this retrospective study covering the period from January 1, 1979 to April 30, 1985The major histologic subtype of lung cancer in this study were similar to those cited by foreign literatures, namely epidermoid cell cancer (37). Adenocarcinoma (25), small cell cancer (20) and large cell cancer (5). By frequency and odds ratio, squamous cell and adenocarcinoma histologies presented with a peripheral radiographic location two times more than with a central location. On the other hand, small cell cancer histology was three times more associated with central radiogaphic presentation. Large cell cancer histology showed to be either centrally or peripherally located without preference. (author)
ABSTRACT
Twenty eight patients (22 males, 6 females), with mean age of 55 years (range 34-71 years) were given combination chemotherapy consisting of Cis-platinum and VP 16-213 (Etoposide). The schedule was Cis-platinum, 20 mg/m2 and VP 16-213, 60 mg/m2, each given for 5 consecutive days and repeated every 4 weeks. Histological subgroups were adenocarcinoma 15, squamous cell carcinoma 9 and large cell carcinoma 4. Prior therapy was radiotherapy in 2 and no treatment in 15 patients. The ECOG performance status was 0-1 in 9 patients and 2-3 in 9 patients. Eight patients had limited disease and 20 had extensive disease. Nine of 28 patients responded, 1 CR and 8 PR's, with an overall response rate of 32%. The median duration of response was 23 weeks. Response rates according to histologic types were similar. Important prognostic factors for response were performance status, stage of the diseases and age below 55 years. Median survival was significantly longer for patients with limited disease vs extensive disease (41 vs 22.5 weeks) and in responders vs non-responders (42 vs 22 weeks). Toxicity was tolerable. This regimen is recommended for subsets of patients with the above prognostic factors.
Subject(s)
Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Bone Marrow/drug effects , Cisplatin/administration & dosage , Etoposide/administration & dosage , Female , Humans , Lung Neoplasms/drug therapy , Male , Middle AgedABSTRACT
The efficacy and tolerability of the combined scheme of administering high dose medroxyprogesterone acetate in advanced breast cancer is evaluated.
Subject(s)
Administration, Oral , Aged , Antineoplastic Agents/administration & dosage , Breast Neoplasms/drug therapy , Female , Humans , Injections, Intramuscular , Medroxyprogesterone/administration & dosage , Medroxyprogesterone Acetate , Middle AgedABSTRACT
Twenty-two patients with advanced or recurrent cancer of the cervix treated with cis-platinum, adriamycin and cyclophosphamide were evaluated. Nine of 22 (41% achieved objective response (2 CR + 7PR), 9/22 (41%) stable disease, 4/22 (18%) progressive disease. The mean duration of response was 24.6 weeks, with a range of 18-28 weeks. Patients with poorly differentiated histologic grade and without previous treatment had better response rates. Responders had longer survival (mean 63.5 + weeks) than nonresponders (mean 30.5 weeks). Commonly encountered toxicities were alopecia, nausea and vomiting, and leucopenia, which were all tolerable.
Subject(s)
Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Carcinoma, Squamous Cell/drug therapy , Cisplatin/adverse effects , Cyclophosphamide/adverse effects , Doxorubicin/adverse effects , Female , Humans , Middle Aged , Neoplasm Recurrence, Local/drug therapy , Uterine Cervical Neoplasms/drug therapyABSTRACT
En 936 angiografias coronarias se encontraron bandas musculares en 46 pacientes.Este informe se refiere a 23 pacientes en los que la banda muscular era la unica alteracion coronaria.En todos ellos las bandas musculares estaban a nivel de la descendente anterior. Se senalan datos angiograficos que distinguen los trayectos intramurales de las grandes arterias, de los datos correspondientes a las bandas musculares epicardicas. Las bandas musculares pueden producir isquemia miocardica.El 82% presentaban cambios isquemicos en el electrocardiograma de reposo. Las pruebas de esfuerzo fueron positivas cuando la obstruccion sistolica era mayor del 70%. Los cambios isquemicos se presentaron en la zona miocardica correspondiente a la arteria estenosada por la banda muscular y en el 60% se acompanaron de disfuncion de la pared ventricular. Los pacientes fueron seguidos por un promedio de 28 meses. La mayoria mejoraron con tratamiento medico a base de betabloqueadores; dos quedaron con angor de esfuerzo