Subject(s)
Animals , Antibody Formation/drug effects , Female , Immunity/drug effects , Immunosuppressive Agents , Male , Plants, Medicinal , RabbitsSubject(s)
Animals , Disease Models, Animal , Female , Gastric Juice/drug effects , Male , Phenothiazines/pharmacology , Rats , Stomach Ulcer/drug therapyABSTRACT
Labetalol, an alpha- and beta- adrenoceptor antagonist was investigated for its central nervous system effects in rats and mice. A marked reduction in the spontaneous motor activity with no concomittant muscle weakness was produced. The drug caused closure of eyelids in rats. Labetalol caused hypothermia and prolonged the pentobarbitone-induced hyposis. In animals trained for conditioned avoidance response the drug blocked the SCR in all the animals and CAR in a few number of animals. The drug did not protect the animals against electroshock convulsions. From the results it appears that labetalol is a central nervous system depressant.
Subject(s)
Animals , Avoidance Learning/drug effects , Body Temperature/drug effects , Central Nervous System/drug effects , Conditioning, Operant/drug effects , Depression, Chemical , Drug Synergism , Ethanolamines/pharmacology , Female , Hypnotics and Sedatives/pharmacology , Labetalol/pharmacology , Male , Mice , Motor Activity/drug effects , Pentobarbital/pharmacology , Rats , Seizures/prevention & controlSubject(s)
Analgesia , Animals , Ethanolamines/pharmacology , Female , Labetalol/pharmacology , Male , Morphine , RatsABSTRACT
Flupenthixol, a new thioxanthene derivative, was studied for its effects on gastric secretion and gastric ulcers in rats. The compound diminished the volume of gastric secretion, decreased total acid output and protected the glandular gastric mucosa. The observations may be of clinical significance.