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Objective@#In this study, a meta analysis was conducted to evaluate and compare the effects of different types of interval training, such as, repeated sprint training(RST), high intensity interval training(HIIT) and sprint interval training(SIT) on body index of overweight/obese college students and the effect of moderate intensity continuous training(MICT), so as to provide a reference for taking appropriate exercise measures.@*Methods@#The data was searched and selected from the database of Web of Science, PubMed, Scopus, The Cochrane Library and CNKI, and from the articles about random research on the effects of HIIT, SIT, RST, and MICT on overweight/obese college students for the evaluation of bias risk. And Stata 16.0 software was used for Meta analysis and network analysis.@*Results@#Totally 815 samples selected from 18 articles were included in the study. Meta analysis showed that HIIT( SMD=-0.26, 95%CI =-0.52--0.00, P <0.05) and SIT( SMD=-0.39, 95%CI =-0.72--0.07, P <0.05) could make greater effects on BMI than MICT. The differences between RST and MICT were of no statistical significance( SMD=0.28, 95%CI =0.32-0.87, P >0.05). According to the SUCRA method combined with effect size, the best effect on improving MetS related physiological indexes of overweight college students was found in SIT( SUCRA =79.3), followed by HIIT( SUCRA =78.2), RST( SUCRA =56.8), and MICT( SUCRA =35.7).@*Conclusion@#Compared with MICT, high intensity interval training can greatly improve BMI of the obese/overweight college students, and could achieve the optimal effect of reducing the fat by exercising through SIT.
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Objective@#To compare the effectiveness of three forms of health education including classroom teaching, network teaching and after class tutoring on exercise behavior among college students.@*Methods@#A literature search was performed using web of science, PubMed, ScienceDirect, Scopus, Cochrane Library, and CNKI database on randomized controlled trials of health education intervention on exercise behavior among college students. Literature filtering, data extraction, and assessment of the risks of bias were conducted by two independent researchers using Stata 16.0 software based on traditional Meta analysis and network meta analysis.@*Results@#A total of 23 literatures were included. The results showed that health education courses could effectively increase the weekly exercise time of college students( SMD =0.29), exercise frequency ( SMD =0.25) and number of students participating in exercise( OR =1.33). Subgroup analysis revealed that the increase in classroom teaching and network teaching associated with increased weekly exercise time ( SMD =0.45, 0.36), exercise frequency ( SMD =0.22, 0.37) and exercise number ( OR =1.36, 1.26)(all P <0.05); The effect of after class tutoring on the time and frequency of weekly exercise was not statistically significant( P >0.05). Indirect comparison showed that the effects of classroom teaching and network teaching on weekly exercise time, and exercise frequency were superior to that of extracurricular counselling( P <0.05); There were no significant differences in the weekly exercise time, frequency and number of participants between the two groups( P >0.05). Based on SUCRA method and the effect size, health education in the form of classroom teaching may have the greatest effect on the weekly exercise time, frequency and the number of students participating in the exercise( SUCRA =91.5, 94.1, 87.1).@*Conclusion@#Health education in the form of classroom teaching and network teaching can positively influence exercise behavior of college students.It is suggested that health education courses should be carried out in college courses so as to better promote college students to participate in physical exercise.
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Objective@#To compare the effects of different types of high-intensity interval training and moderate-intensity steady training on improving cardiorespiratory fitness of college students, and to provide evidence supporting intervention methods for health promotion of college students.@*Methods@#By using the method of Meta-analysis, Web of science, PubMed, Scopus and CNKI database was searched for randomized control trails regarding high-intensity intervention (HIIT), repeated-sprint training (RST) and sprint-interval training (SIT) among sedentary college students in April 1, 2020. Two independent researchers conducted literature filtering, data extraction, risk of bias assessment, as well as traditional Meta-analysis and network Meta-analysis by using Stata software version 16.0.@*Results@#A total of 21 articles and 728 participants were included. Meta-analysis showed that HIIT (SMD=0.35, 95%CI=0.10-0.60, P<0.05) and SIT (SMD=0.38, 95%CI=0.05-0.70, P<0.05) were significantly better than MICT, there was no statistical difference in RST (SMD=-0.08, 95%CI=-0.41-0.25, P>0.05) compared with MICT; HIIT (SMD=0.40, 95%CI=0.08-0.72, P<0.05) and SIT (SMD=0.35, 95%CI=0.03-0.67, P<0.05) were significantly better than RST, there was no significant difference between HIIT and SIT(SMD=0.05, 95%CI=-0.25-0.36, P>0.05). The ranking of the four training methods for improving the effect size of VO 2max index was HIIT>SIT>RST>MICT.@*Conclusion@#The overall effect of high intensity interval training on VO 2max is better than MICT, and HIIT training may be the best.
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Objective@#The aim of this study was to investigate the effects of smoking and aerobic exercise on metabolic syndrome risk factors among male college students.@*Methods@#Eighty male college students were randomly selected from Global Youth Tobacco Survey and assigned to exercise smoker(ES), non-exercise smoker(NES), exercise non-smoker(ENS) and non-exercise nonsmoker (NENS) groups with sample size of 20 in each group. Subjects in NES and NENS groups maintained daily lifestyle while those in ES and ENS group performed aerobic exercise 5 times per week for 8 weeks with exercise intensity set at 50%~80% of heart rate reserve. Before and after experiment, risk factors for metabolic syndrome were assessed including systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), fasting plasma glucose (FPG), triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C).@*Results@#After experiment, compared with ENS and NENS group, WC, SBP, DBP, FPG and TG increased while HDL-C decreased (P<0.05) in ES and NES groups. Compared with pre-experiment, SBP and DBP significantly decreased in ENS group(P<0.05), increased in NES group (P<0.05) while no statistically significant in ES and NENS group(P>0.05); WC was significantly reduced in both ES and ENS groups(P<0.05), increased in NES group (P<0.05) while no statistically significant in NENS group (P>0.05) after experiment. Compared with NES and NENS groups, △WC in ES and ENS group decreased (P<0.05); compared with other groups, △SBP and △DBP increased in NES groups while decreased(P<0.05) in ENS group.@*Conclusion@#Smoking is associated with higher level of metabolic syndrome risk factors, while aerobic exercise is associated with lowering blood pressure and WC level in male college students.
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@#In recent years, due to precise control of the amorphous mineral precursor in the demineralization of dentine collagen fibers in orderly deposition, forming apatite crystals similar to the natural mineralized dentin, the bottom-up remineralization approach which does not depend on the existence of seed crystallites, dentin biomimetic mineralization techniques gradually become a hotspot in the research field of restoration of demineralized dentin caused by dental caries. This paper reviews the changing concepts and practices of the remineralization of demineralized dentin, emphasizing biomimetic remineralization studies. The results of the literature review show that the traditional dentin remineralization method is usually a disordered mixture of demineralized dentin and minerals, so mineralized dentin is not comparable to natural mineralized dentin in terms of the morphological characteristics and mechanical properties. With its gradual increase in recent years, dentine biomimetic mineralization technology perfectly resembles the minerals in the dentin overlapping sequence arranged with the dentine collagen fiber structure characteristics, leading to greatly improved microstructural, physical and chemical properties. As a result, dentine biomimetic mineralization technology is expected to achieve new breakthroughs in the fields of resin-dentin bonding mixing layers and the decay of dentin. At present, the technical obstacles that need to be overcome in the clinical application of the biomimetic remineralization of dentin are how to continuously supplement all the active ingredients needed for mineralization in the process of remineralization and how to keep the mechanical properties of the parent material unchanged while slowly releasing all ingredients. Researchers have successively proposed three-step transportation of the biomimetic remineralization of raw materials, as well as the preparation of mineralization precursors stabilized by polymers in advance and the reuse of mesoporous silicon nanomaterials for the transportation of the mineralized ingredient system. The concept described above provides the preliminary in vitro experimental basis for the transformation of the biomimetic remineralization strategy of dentin in clinical applications.
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Objective@#To investigate the effect of a 12-week circuit training program on health-related physical fitness and metabolic syndrome risk factors in obese female college students,and to provide reference for targeted interventions.@*Methods@#Sixty subjects with body mass index (BMI) over 28 kg/m2 were randomly allocated to control group ( n =30) or exercise group( n =30). Participants of control group maintained daily lifestyle while those of exercise group performed circuit training program 3 times per week for 12 weeks. Parameter of body composition (including back strength, sit-up, sit-and-reach, and 1 600 m running time), health-related physical fitness (including body height, body weight, BMI), percentage of body fat (PBF) and lean body mass (LBM) and metabolic syndrome risk factors [including waist circumference(WC), fasting blood glucose(FBG), triglyceride(TG), total cholesterol(TC), highdensity lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)] were tested before and after the experiment.@*Results@#After intervention, body weight, BMI, PBF decreased, back strength, sit-up, sit-and-reach, and 1 600 m running time performance increased( t =2.14, 2.21, 2.48, -7.21, -7.69, -7.01, 4.83, P <0.05), WC, TG, TC reduced in exercise group compared with pre-test( t =2.89，4.54，2.71， P <0.05), whereas all parameters in control group showed no significantly different( P >0.05).@*Conclusion@#Regular circuit training improved body composition, enhanced physical fitness and may contribute to prevent metabolic diseases.
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SUMMARY BACKGROUND: This study aims to investigate the expression of Id-1 in human colorectal adenocarcinoma tissues and explore its correlation with the clinical pathological parameters of colorectal cancer. METHODS: The Id-1 mRNA and protein expression levels of 50 specimens of normal colorectal tissues and 50 specimens of colorectal adenocarcinoma tissues were detected using reverse-transcription polymerase chain reaction and western blot. Furthermore, Id-1 protein was detected using immunohistochemistry. The correlation between the expression of Id-1 and clinicopathologic features was analyzed. RESULTS: The mRNA expression level of Id-1 in colorectal adenocarcinoma tissues and normal colorectal tissues was 0.96 ± 0.03 vs. 0.20 ± 0.04, respectively; and the difference was statistically significant (P=0.011). Furthermore, Id-1 protein expression was higher in colorectal adenocarcinoma tissues than in normal colorectal tissues (0.82 ± 0.04 vs. 0.31 ± 0.02, P=0.020). In addition, the positive protein expression rate of Id-1 was higher in colorectal adenocarcinoma tissues than in normal colorectal tissues (72.00% vs. 24.00%, X2=23.431, P=0.000). The expression of Id-1 was correlated with the depth of tumor invasion, TNM stage, lymph node metastasis, vessel invasion, and liver metastasis (P<0.01). However, this expression was not correlated with tumor size and differentiation degrees (P>0.05). CONCLUSIONS: The high Id-1 expression in colorectal adenocarcinoma tissues play an important role in the process of cancer, and is expected to become a new tumor monitoring indicator for clinical diagnosis, treatment, and prognosis judgment.
RESUMO OBJETIVO: O objetivo deste estudo é investigar a expressão de Id-1 em tecidos de adenocarcinoma colorretal em humanos e investigar sua correlação com os parâmetros patológicos clínicos de câncer colorretal. MÉTODOS: Os níveis de expressão de proteína e mRNA Id-1 em 50 amostras de tecido colorretal normal e 50 amostras de tecido de adenocarcinoma colorretal foram detectados através de reação em cadeia de polimerase precedida de transcrição reversa e western blot. Além disso, a proteína Id-1 foi detectada através de imuno-histoquímica. A correlação entre a expressão de Id-1 e características clínico-patológicas foi analisada. RESULTADOS: O nível de expressão de mRNA Id-1 em tecidos de adenocarcinoma colorretal e tecidos colorretais normais foi de 0,96 ± 0,03 versus 0,20 ± 0,04, respectivamente; a diferença foi estatisticamente significativa (P= 0,011). Além disso, a expressão da proteína Id-1 foi maior em tecidos de adenocarcinoma colorretal do que em tecidos colorretais normais (0,82 ± 0,04 versus 0,31 ± 0,02, P= 0,020). Além disso, a taxa de expressão positiva de proteínas Id-1 foi maior em tecidos de adenocarcinoma colorretal do que em tecidos colorretais normais (72,00% vs. 24,00%, X2=23,431, p=0,000). A expressão de Id-1 foi correlacionada com a profundidade da invasão tumoral, estágio TNM, metástases linfonodais, invasão vascular e metástase hepática (P<0,01). Todavia, essa expressão não se correlacionou com o tamanho do tumor e graus de diferenciação (P>0,05). CONCLUSÃO: A alta expressão de Id-1 em tecidos de adenocarcinoma colorretal desempenham um importante papel no processo do câncer, e é esperado que se torne um novo indicador de monitoramento de tumores para o diagnóstico clínico, tratamento e estimativa de prognóstico.
Subject(s)
Humans , Male , Female , Adult , Aged , Colorectal Neoplasms/pathology , Adenocarcinoma/pathology , Inhibitor of Differentiation Protein 1/analysis , Reference Values , Immunohistochemistry , Biomarkers, Tumor/analysis , Blotting, Western , Reverse Transcriptase Polymerase Chain Reaction , Middle Aged , Neoplasm StagingABSTRACT
Objective@#The present study aims to investigate the association of functional exercise performance and pulmonary function in obese children, and to provide a reference for improving motor ability of obese children.@*Methods@#A total of 55 obese (obese group) and 57 healthy children with normal body weight (control group) were enrolled and pulmonary function as well as functional exercise performance were determined by spirometry and six-minute walk test (6 MWT), respectively.@*Results@#The 6 MWT distance (6MWD) in obese group was lower than that of control group [obese group (546.1±67.9)m, control group (610.4±70.1)m, P<0.01]. In terms of pulmonary function parameters, forced expiratory volume in 1 sec (FEV1) and forced mid-expiratory flows (FMEF) were lower in the obese group than control group [FEV1: obese group (93.3±9.4)%, control group (99.5±16.4)%, P=0.02; FMEF: obese group (100.2±11.4)%, control group (109.4±19.1)%, P=0.002], whereas forced vital capacity (FVC), the FEV1/FVC ratio and peak expiratory flow (PEF) were not statistically different between the two groups. Partial correlation analysis revealed that among all parameters, only body mass index (BMI) was negatively associated with 6MWD(r=-0.31, P=0.03).@*Conclusion@#Functional exercise performance and pulmonary function of obese children deteriorates as compared to those of healthy children. BMI might be the independent predictor for functional exercise performance.