Effect of Allium Cepa on blood Glucose levels of normal and Alloxan treated Diabetic rabbits

The aquous solution of dried powder of the Allium cepa was administered in doses of 100, 150 and 200 mg/kg body weight to normal and alloxan treated diabetic rabbits. The blood glucose levels were estimated before and 2,4,6 and 8 hours after the administration of the solution. The solution exerted a significant [P< 0.05] hypoglycaemic effect in both normal and diabetic rabbits. In normal rabbits, oral administration of 150 and 200 mg/kg doses caused decrease in blood glucose levels at 2,4,6 and 8 hours, while maximum decrease was at 6 hours. In the alloxan treated diabetic rabbits, 200 mg/kg dose only could produce significant decrease at 4,6 and 8 hours while maximum decrease was at 6 hours. The doses used did not show acute toxicity or behavioral changes. It may be concluded that the plant contains one or more hypolglycaemic principles which can reduce the blood glucose in normal rabbits and in those with alloxan induced diabetes

Pharmacological screening of some indigenous plants for anti-diabetic activity

This study deals with the effects of alcoholic extracts of seven indigenous plants on blood glucose levels of normal and alloxan-diabetic rabbits. The blood glucose levels were estimated before and 2,4,6 and 8 hours after the administration of a single 500 mg / kg oral dose. The extracts of six plants had no significant [P> 0.1] hypoglycaemic effect in normal as well as alloxan-diabetic rabbits. The extract of one plant i.e. Momordica Charantia, however, exerted a significant [P < 0.05] hypoglycaemic effect in both normal and alloxan diabetic rabbits. From this study this may be concluded that Momordica charantia can be effective in the control of diabetes mellitus

Effects of acacia arabica and caralluma edulis on blood glucose levels of normal and alloxan diabetic rabbits

The powdered seeds of Acacia arabica and roots of Caralluma edulis were administered in doses of 2, 3 and 4 gm/kg body-weight to normal and ailoxan-diabetic rabbits. The blood glucose levels were estimated before and 2, 4, 6 and 8 hours after the administration of plant suspension. The powdered seeds of Acacia arabica exerted a significant [P <0.05] hypoglycemic effect in normal rabbits. The hypoglycemic effect was not significant [P >0.01] in alloxan diabetic rabbits. The powdered roots of Caraliuma edulis did not produce any significant [P >0.01] hypoglycaemic effect in normal as well as in alloxan diabetic rabbits. The doses used did not show any acute toxicity and behavioural changes. From this study it may be concluded that the powdered seeds of Acacia arabica act by initiating the release of insulin from pancreatic beta cells of normal rabbits. Moreover, Carallunria edulis did not show any hypoglycaemic effect in normal as well as in diabetic rabbit